文章摘要
余章斌,韩树萍,郭锡熔.中国人群先天性心脏病危险因素的Meta分析[J].中华流行病学杂志,2008,29(11):1137-1140
中国人群先天性心脏病危险因素的Meta分析
A Meta-analysis on the risk factors of perinatal congenital heart disease in Chinese people
收稿日期:2008-06-29  出版日期:2014-09-11
DOI:
中文关键词: 先天性心脏病;Meta分析;危险因素;比值比
英文关键词: Congenital heart disease;Meta-analysis;Risk factor;Odds ratio
基金项目:
作者单位
余章斌 南京医科大学附属南京妇幼保健院儿科, 210004 
韩树萍 南京医科大学附属南京妇幼保健院儿科, 210004 
郭锡熔 南京医科大学附属南京妇幼保健院儿科, 210004 
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中文摘要:
      目的 探讨中国人群先天性心脏病发生的主要危险因素,为该病防治提供依据.方法 利用Meta分析方法分析国内12篇(累计病例3436例,对照3976例)关于先天性心脏病发病危险因素的研究文献.根据齐性检验结果采用计算各危险因素合并OR值及其95%CI.结果 单因素合并OR值分别为:母孕期受精神刺激(4.55)、母孕早期有感冒病史(3.18)、孕前接触有毒化合物(3.19)、孕期接触农药(4.85)、孕期有负性生活事件(5.39);多因素合并OR值分别为:母孕期受精神刺激(4.08)、孕期接触有毒化合物(3.54)、母孕期感冒发热(5.00).结论 目前影响中国人群先天性心脏病发生的主要因素为母孕期受精神刺激、母孕早期有感冒病史或发热、孕前或孕期接触有毒化合物、孕期接触农药和孕期有负性生活事件.
英文摘要:
      Objective To investigate the main risk factors related to the incidence of perinatal congenital heart disease (CHD) in Chinese people. Methods Results on the risk factors of CHD in 12 papers were analyzed by Meta-analysis method. The cumulative cases and controls were 3436 and 3976, respectively. The calculation methods of the combined odds ratio( OR ) and 95 % confidence interval (CI) were determined according to the homogeneity test. Results The pooled OR values of single-factor-analysis were as follows: spiritual stimulus ( 4.55 ), maternal exposures to pesticides ( 4.85 ), negative life events (5.39) during pregnancy, cold (3.18) during early pregnancy, exposure to chemical toxic substances before pregnancy. The pooled OR values of multiple-factor analysis were as follows: spiritual stimulus (4.08), exposure to chemical toxic substances ( 3.54 ), cold with fever ( 5.00 ) during pregnancy. Conclusion The main factors influencing the incidence of CHD in Chinese people were current spiritual stimulus, exposure to chemical toxic substances or pesticides, negative life events during pregnancy, cold or fever during early pregnancy, exposure to chemical toxic substances before pregnancy.
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