文章摘要
星一,刘民.流感灭活疫苗在中国应用效果的Meta分析[J].中华流行病学杂志,2009,30(4):368-370
流感灭活疫苗在中国应用效果的Meta分析
Meta analysis on the effectiveness of inactivated influenza vaccine
收稿日期:2008-09-19  出版日期:2014-09-17
DOI:
中文关键词: 流感疫苗;疫苗效果;Meta分析
英文关键词: Inactivated influenza vaccine;Vaccine effectiveness;Meta analysis
基金项目:
作者单位
星一 北京大学医学部公共卫生学院 100191 
刘民 北京大学医学部公共卫生学院 100191 
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中文摘要:
      了解流感疫苗免疫效果。方法对国内1998年3月至2008年5月公开发表的符合入选标准的有关流感疫苗免疫效果的研究文献,根据各研究结果的同质性,利用随机效应模型或固定效应模型进行Meta分析。结果初筛选出16篇文献,有13篇文献符合入选标准,11篇为队列研究,2篇为随机对照研究。对队列研究进行Meta分析发现流感疫苗预防流感样疾病效果,儿童为66%(51%~76%),成年人47%(25%~63%),老年人53%(20%~72%)。结论流感疫苗可有效预防各年龄段流感样疾病的发生。
英文摘要:
      understand the effectiveness of inactivated influenza vaccines (IIV).Methods We did a Meta analysis on IIV effectiveness with papers published during March 1998 and May 2008 in Chinese journals,using fixed model or random model according to the heterogeneity of the studies.Results A total number of 13 studies were included,of which 11 were cohort studies and 2 were randomized controlled trials.Through Meta analysis on cohort studies regarding the effectiveness against influenza like illness (ILI),we noticed that the effectiveness of the vaccine was 66% (95%CI:51%-76 % ) in children and adolescents,but 47 % (25 %-63 % ) in adults,and 53 % (20%-72%) in the elderly.Conclusion IIV was effective in protecting against influenza like illness.
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