文章摘要
黄定,付真彦,杨毅宁,谢翔,王迎红,马依彤.CYP4F2基因单体型与心肌梗死的相关性研究[J].中华流行病学杂志,2009,30(7):733-736
CYP4F2基因单体型与心肌梗死的相关性研究
Association on the haplotypes of CYP4F2 gene and myocardial infarction
收稿日期:2008-12-03  出版日期:2014-10-16
DOI:10.3760/cma.j.issn.0254-6450.2009.07.023
中文关键词: 心肌梗死;CYP4F2;单体型;病例对照
英文关键词: 
基金项目:新疆维吾尔自治区重大科技等项课题(200733146)
作者单位
黄定 乌鲁木齐, 新疆医科大学第一附属医院心脏中心 
付真彦 乌鲁木齐, 新疆医科大学第一附属医院心脏中心 
杨毅宁 乌鲁木齐, 新疆医科大学第一附属医院心脏中心 
谢翔 乌鲁木齐, 新疆医科大学第一附属医院心脏中心 
王迎红 乌鲁木齐, 新疆医科大学第一附属医院心脏中心 
马依彤 乌鲁木齐, 新疆医科大学第一附属医院心脏中心 
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中文摘要:
      目的 研究CYP4F2基闲单体型与心肌梗死的关系。方法 250例心肌梗死患者和250例对照分别分为整体组、男性组、女性组。选择CYP4F2基因的5个SNPs(rs3093105、rs3093135、rsl558139、rs2108622、rs3093200), 应用TaqMan SNP基因分型方法 进行基渊分型, 并应用病例对照单体型分析方法 进行相关性研究。结果 对于男性, 心肌梗死患者rs2108622的G等位基因频率远远高于对照(P=0.005);心肌梗死患者和对照相比较, 单体型的总体分布在男性组昆著不同(P=0.002);男性组心肌梗死患者的T-C.G单体型频率最著高于对照(P=0.002), 男性组心肌梗死患者的T-C.A单体型频率显著低于对(P=0.003)。结论 CYP4F2基因rs2108622的G等位基因叮能与男性心肌梗死相关, T-C.G单体型可能是男性心肌梗死的遗传标记。
英文摘要:
      Objective The aim of this study was to assess the association between human CYP4F2 gene and myocardial infarction(MI).using a haplotype-based case.control study.A separate analysis on gender was also carried out.Methods There were 250 MI patients and 250 control SUbjects genotyped for 5 SNPs of the human CYP4b 2 gene(rs3093105, rs3093135, rsl558139, rs2108622, rs3093200).Data were assessed on 3 separate groups:the total subjects, men and women.Results For men.G allele was significantly higher in the MI patients than in the control subjects and the overall distribution of the haplotypes was significantly difierent between the MI patients and the control subjects (P=0.002).AIso in men。the frequency of T-C-G haplotype was significantly higher for MI patients than for control subjects(P=0.002).and the frequency of T.C.A haplotype was significantly lower for Ml patients than for control subjects(P=0.003).Conclusion Data from the present Results indicated that M1 was associated with G allele of rs2 1 08622 in men.suggesting that 3-C-G haplotype might serve as genetic marker for MI in men.
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