细胞色素P4501A1基因多态性与食管癌易感性关系的Meta分析

代丽萍; 王彦平; 吴晓冰; 王凯娟; 吕全军

文章摘要

代丽萍,王彦平,吴晓冰,王凯娟,吕全军.细胞色素P4501A1基因多态性与食管癌易感性关系的Meta分析[J].中华流行病学杂志,2009,30(11):1198-1202

细胞色素P4501A1基因多态性与食管癌易感性关系的Meta分析

Study on the association of cytochrome P450 polymorphisms and the risk of esophageal cancer：a meta-analysis

收稿日期:2009-03-18 出版日期:2014-09-17

DOI：

中文关键词: 食管癌 CYPlAl 基因多态性 Meta分析

英文关键词: Esophageal cancer CYPlAl Gene polymorphism Meta-analysis

基金项目:国家自然科学基金(30872181)|教育部"211工程"项目|河南省科技攻关计划项目(031161200)

作者	单位	E-mail
代丽萍	郑州大学公共卫生学院
王彦平	河南省农业职业学院食品科学系, 450001
吴晓冰	郑州大学公共卫生学院
王凯娟	郑州大学公共卫生学院
吕全军	郑州大学公共卫生学院	lqjnutr@zzu.edu.cn

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中文摘要:

目的探讨细胞色素P4501AI(CYPIAl)MSpl和lle/Val位点基因多态性与食管癌发生的关系.方法采用Meta分析方法,对国内外1997-2008年采用病例对照方法研究CYPIAl Mspl和llelVal基因多态性与食管癌发生关系的16篇(Mspl 8篇,lle/Val 14篇)文献,采用显性模型(即突变基因型与野生型比较)进行综合定量分析,然后按病理分型(鳞癌/腺癌)分亚组进行分析.结果综合分析CYPlAl Mspl突变基因型(TC+CC)与食管癌发生无统计学关联(OR=1.17,95%CI :0.82-1.66),亚组分析亦未发现CYPIAl Mspl突变基因型与食管鳞癌(OR=1.17,95%CI:0.82-1.69)和食管腺癌(OR=1.39,95%CI: 0.67-2.09)的统计学关联|携带CYPIAl突变基因型(Ile/Val+Val/Val)的个体发生食管癌的危险性是野生型的1.39倍(OR=1.39,95%CI:1.07～1.80)|亚组分析显示突变基因型与食管鳞癌发生的易感性相关但与食管腺癌无关联,OR值分别为1.43(95%CI:1.07～1.91)和1.20(95%CI :0.62～2.30).结论CYPlAl lle/Val位点突变基凶型可增加食管鳞癌发生的危险性,CYPIAl Mspl位点基因多态性与食管癌无关联.

英文摘要:

Objective To examine the association between CYPlAI polymorphisms(Mspl and lle/Val)and esophageal cancer(EC)by systematically reviewing the risk of the original studies.Methods Data from 16 papers(8 for Mspl,14 for lle/VaL)regarding case.control studies on the association of cytochrome P450 polymorphisms and risk of esophageal cancer was analyzed by dominant model(variant genotype vs. wild-type genotype)through meta-analysis.Stratified analysis was carried out according to the pathological types. Results In systematicaI analysis.CYPIAI MspI variant genotype(TC+CC)had no association with ECrisk(OR=1.17.95%ORResults were observed in esophageal squamous-cell carcinoma(ESCC)(OR=1.17, 95%CI：0.82-1.69)and esophageal adenocarcinoma(EAC)(OR= 1.39.95%CI0.67-2.09).Individuals with the CYPlAl Ile/Val variant genotype(Ile/Val+Val/Val)had an increased risk for EC.when comparing with wild type(Ile/Ile), with an OR of l.39(95%CI：1.07-1.80).CYPIAI Ile/Val variant genotype couldincrease the risk of ESCC (OR=1.43.95%CI：1.07-1.91)but no significant association was found with EAC(OR=1.20, 95%CI:0.62-2.30). Conclusion CYPIAI gene polymorphism Ile/Val might have played a role in the development of ESCC but CYPIAI Mspl polymorphism might not be associated with the susceptibility of EC.

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