| 许少洪,孙凤琪,计国欣.广州市海珠区罕见沙门菌的发现及鉴定[J].中华流行病学杂志,2009,30(12):1316 |
| 广州市海珠区罕见沙门菌的发现及鉴定 |
| A case-control study of endogenous estrogen and risk of Alzheimer' s disease |
| 收稿日期:2009-06-15 出版日期:2014-09-24 |
| DOI： |
| 中文关键词: 阿尔茨海默病 雌激素 流行病学 |
| 英文关键词: Alzheimer' s disease Estrogen Epidemiology |
| 基金项目: |
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| 中文摘要: |
| 对广州市海珠区健康人群1998-2008年沙门菌带菌情况调查及菌型研究. |
| 英文摘要: |
| Objective To investigate the risk of Alzheimer's disease (AD) associated with endogenous estrogen. Methods A population based,m:n matched case control study was conducted, including 115 female AD patients identified from sample population aged 55 years or older as cases and 1 041 non cognitive impairment individuals from same population matched for age and sex as controls. Results Age at natural menopause had significant effect on AD using multivariate analysis. The odds ratio ( OR ) for AD was 0.672 for individuals whose age at natural menopause were between 47 to 50 years old, compared with individuals whose age at menopause were less than 47 years old. The OR was 0.452 for individuals whose age at menopause were more than 50 years old comparing with individuals whose age at menopause were less than 47 years old ( P = 0.020 7 ). The OR for AD increased parallel to the increase of age at menarche (adjusted OR = 1.160 for each increased year, P = 0.034 2 ). Conclusion The decrease of endogenous level in postmenopausal women might serve an etiological factor for AD. |
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