文章摘要
张薇,项永兵,方茹蓉,程家蓉,袁剑敏,高玉堂.液体总摄人量和小便次数与上海市区居民膀胱癌危险性的关系[J].中华流行病学杂志,2010,31(10):1120-1124
液体总摄人量和小便次数与上海市区居民膀胱癌危险性的关系
TotaI fluid intake.urination frequency and risk of bladder cancer:a population-based case.control study in urban Shanghai
收稿日期:2010-05-20  出版日期:2014-09-18
DOI:10.3760/cma.j.issn.0254-6450.2010.10.O11
中文关键词: 膀胱肿瘤;吸烟;液体总摄人量;小便次数;病例对照研究
英文关键词: Bladder neoplasms;Smoking;Total fluid intake;Urination frequency;Casecontrol study
基金项目:世界卫生组织.瑞典国际开发合作署资助项目(wP/2006/(:HN/HIv/1.2/002/03.03.AW.01);国家高科技“863”课题资助项目(2006AA027.418)
作者单位E-mail
张薇 200032 上海交通大学肿瘤研究所上海市肿瘤研究所 ybxiang@shsci.Org 
项永兵 200032 上海交通大学肿瘤研究所上海市肿瘤研究所  
方茹蓉 200032 上海交通大学肿瘤研究所上海市肿瘤研究所  
程家蓉 200032 上海交通大学肿瘤研究所上海市肿瘤研究所  
袁剑敏 美国明尼苏达大学公共卫生学院流行病学和社区卫生系  
高玉堂 200032 上海交通大学肿瘤研究所上海市肿瘤研究所  
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中文摘要:
      目的 探讨液体总摄人量和小便次数与上海市区居民膀胱痈危险性的关系。方法 采用伞人群病例对照研究,共调企1996年1月1日至1998年12月31日期间诊断的上海市区膀胱 癌新发病例608例,以及性别、年龄配对的人群对照607名。采用非条件logistic回归模型,调整可能的混杂因素,估计液体总摄人量和小便次数与膀胱癌发生的OR值及95%CI(a=0.05)。结果 每天液体总摄人量及夜晚(即睡眠时间内)小便次数与膀胱癌发生的危险性无统计学意义的相 关。白昼(即1F睡眠时间内)通常小便次数与膀胱癌危险性呈负相关。调整年龄、性别、是否吸 烟、液体总摄入量及其他因素后,与白昼通常小便次数≤3次者相比,小便次数为4、5及>16次者 的OR值分别为0.72(95%C1:0.49~1.05)、0.60(95%CI:0.41~0.87)和0.62(95%CI:0.43-0.90),趋 势检验有统计学意义(P=0.014)。与白昼通常小便次数≤3次者相比,白昼通常小便次数≥6次 的吸烟者和不吸烟者的OR值分别为0.72(95%C/:0.45-1.15)和0.46(95%CI:O.25~0.87)。与每 天液体总摄入量≤750 ml且白昼通常小便次数≤3次者相比,每天液体总摄人量>1500 ml且白 昼通常小便次数>/6次者膀胱癌的危险性降低了57%,有统计学意义的相火性。结论 不憋尿且 多饮水,尤其不吸烟者可以降低膀胱癌发牛的危险性。
英文摘要:
      Objective To evaluate the association between total fluid intake and the time of urination per day and the risk of bladder cancer.Methods A population-based case-control study was conducted in urban Shanghai.China.during January l 996 to December 1 998.The study included 608 incident cases of bladder cancer and 607 age.and sex.matched controls.Unconditional logistic regression models were used to estimate the odds ratios(ORs)and their corresponding 95% confidence intervals(95%CIs)for bladder cancer associated with frequency of urination,after adjusted for age。gender。smoking status,history of occupation with high risk,history of bladder infections.body mass index and other confounding factors.The level of statistical significance was set at 0.05(two.sided).Results No significant fiend was observed for the association between toml fluid intake.time of nighttime urination and the risk of bladder cancer.Increasing time of urination during daytime was associated with decreased risk of bladder cancer(P for trend=0.014).ORs (95%C/s)for subjects who voided 4 times,5 times and 6 or more times per day[O.72(0.49-1.05), 0.60(0.4 1一O.87)and 0.62(0.43-0.90),respectively I,when compared with those with less than 4 times per day after adjustment of confounding factors.Data showed that smokers and nonsmokers who voided at least 6 times per day had the O尺s of 0.72(95%Cy:0.45-1.15)and 0.46(95%(V: 0.25一O.87)when compared to their counterparts who voided 3 times or less per day during the daytime.Subjects who urinated at least 6 times per day and consumed more than 1 500 ml of total fluid per day experienced a significant 57%reduction iu risk compared to subjects who urinated 3 times or less and consumed less than 750 ml of total daily fluid intake.Conclusion Increasedurination frequency and total fluid intake,especially among those who never smoked might be associated with a reduced risk of bladder cancer.
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