文章摘要
向阳,孙凤,詹思延.谷胱甘肽S一转移酶M1、T1基因多态性与抗结核药物所致肝损害易感性的Meta分析[J].中华流行病学杂志,2010,31(10):1997-1200
谷胱甘肽S一转移酶M1、T1基因多态性与抗结核药物所致肝损害易感性的Meta分析
Meta-analysis on the relationship between polymorphisms of Giutathione S-transferase M1 and T1 genes and the susceptibility to antituberculosis drug-induced liver injury
收稿日期:2010-03-04  出版日期:2014-09-18
DOI:10.3760/cma.j.issn.0254—6450.2010.10.029
中文关键词: 抗结核药物所致肝损害;谷胱甘肽s一转移酶;基因多念性;Meta分析
英文关键词: Antituberculosis drug-induced liver injury;Glutathione S-transferase;Genetic polymorphism;Metaanalysis
基金项目:国家自然科学基金(30960328)
作者单位E-mail
向阳 83001l 乌鲁木齐, 新疆医科大学公共卫生学院流行病学与卫生统计学教研窜 siyan-zhan@bjmu.edu.cn 
孙凤 北京大学公共卫生学院流行病与卫生统计学系  
詹思延 北京大学公共卫生学院流行病与卫生统计学系  
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中文摘要:
      结核病目前仍然是严重危害人类健康的公共卫生问题。研究发现,WHO推荐的标准短程化疗方案主要使用的三种一线药物异烟肼、利福平、吡嗪酰胺,均能引起不同程度、不同频度的不良反应,其中最主要的不良反应是肝损害。
英文摘要:
      Objective Through introduction of principal theory and algorithm of propensity score to design SAS macro programs for binary data.Methods Propensity score method was used to compare the differences of character variables between two groups, and the association of DNR (Do Not Resuscitate) with the mortality of congestive heart failure was evaluated with different methods.Results Significant differences among the character variables between two groups were effectively balanced with stratification or matching method. The odds ratios of DNR with the in-hospital mortality rate of congestive heart failure were estimated identical with different algorithms and to find that the association of DNR to in-hospital mortality was highly significant. Conclusions Propensity score was a good algorithm that could be used to analyze any kind of observational data for matching the effects among the character variables.
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