文章摘要
胡志坚,薛金发,张小阳,史习舜,周红.ERCC1基因多态性与肝癌易感性研究[J].中华流行病学杂志,2010,31(11):1288-1291
ERCC1基因多态性与肝癌易感性研究
Relationship between genetic polymorphism of ERCC1 and susceptibility to liver cancer
收稿日期:2010-04-28  出版日期:2014-09-10
DOI:
中文关键词: 肝肿瘤  病例对照研究  基因多态性
英文关键词: Liver cancer  ERCCl  Case-control study  Gene polymorphism
基金项目:福建省G然科学基金(C0710019);福州市科技资助项S(2006S-G24)
作者单位E-mail
胡志坚 福建眹科大学流行病与卫生统计系, 福州 350004 hzj99955888@126.com 
薛金发 福州市卫生监督所  
张小阳 福州市卫生监督所  
史习舜 福建眹科大学流行病与卫生统计系, 福州 350004  
周红 福州市卫生监督所  
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中文摘要:
      目的 研究ERCCI基因多态性与福州地K人群肝癌易感性之间关系, 及其与环境因素交互作用对肝癌发牛的影响。方法 采用病例对照研究收集病例和对照暴露信息, 采用聚合_链反应限制性片段K度多态性(PCR-RFLP)技术对ERCCI-C8092A基因多态性进行检测;通过广义线性模拟ERCCI-C8092A基因多态性与肝癌主要环境危险因素交互作用的结构模型。结果 以ERCCI-C8092ACC作为参照, ERCCI-C8092ACA/AA基因型可以增加原发性肝癌的发病危险性(OR=3.789, 95%a:2.792?5.142);ERCCI-C8092A突变与饮沟塘水、乙型肝炎病毒感染的联合作用最适模均为超相加模墦, 与霉变食品联合作用为超相乘模型。结论 ERCCI-C8092A多态可能与肝癌遗传易感有关, 并与肝癌主要环境闵素间存在协同作用。
英文摘要:
      Objective To investigate the association between genetic polymorphisms of ERCCI-C8092A and susceptibility to liver cancer, as well as the gene-environmental interaction on the etiology of liver cancer in Fuzhou. Methods A case-control study was conducted to collect the information on environmental exposure while genetic polymorphism of ERCCl was analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. General relative risk regression models were further applied to fit the interaction between genetic polymorphisms of ERCCI-C8092A and the environmental factors of liver cancer. Results ERCCI-C8092A variant genotypes were associated with significant increasing risk of liver cancer adjusted odds ratio(0R=3.789, 95%CI:2.792-5.142), compared to the wild-type homozygote. Data from the analysis of interaction showed that genetic polymorphism of ERCCI-C8092A appeared super?additive interaction with drinking pond-ditch or with hepatitis B, and super-multiplicative interaction with eating moldy food. Conclusion The point mutation in ERCC卜8Q92A was possibly susceptible to liver cancer, and related synergistically with other risk factors in hepatocelluar carcinogenesis in Fuzhou.
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