| 梁建华,王呜,刘建华,蔡衍珊,许建雄.广州市20～59岁人群乙型肝炎疫苗接种状况及其疫苗保护效果分析[J].中华流行病学杂志,2010,31(12):1336-1339 |
| 广州市20～59岁人群乙型肝炎疫苗接种状况及其疫苗保护效果分析 |
| Study on the immunization coverage and effects of hepatitis B vaccine in the 20一59 years-old population tn Guangzhou city |
| 收稿日期:2010-07-20 出版日期:2014-09-18 |
| DOI：10.3760/cma.j.issn.0254-6450.2010.12.003 |
| 中文关键词: 乙型肝炎疫苗 效果 病例对照研究 |
| 英文关键词: Hepatitis B vaceine Efficacy Case-control study |
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| 中文摘要: |
| 目的了解广州市非新生儿人群乙型肝炎(乙肝)疫苗(HepB)接种状况并评价其保护效果.方法在广州市12个区、县级市按照多阶段分层整群抽样法,以家庭为单位对20—59岁人群进行横断面调查.并检测HBsAg、抗一HBs;对HepB接种史及主要乙肝感染危险因素进行问卷调查,采用抽样权重评估20一59岁人群HepB接种率,HBsAg、抗一HBs流行率.通过病例对照研究,评价疫苗保护效果.结果广州市20一59岁人群有HepB接种史为24.71%(95%CI:.86%~28.56%),HBsAg流行率14.91%(95%CI:12.73%~17.08%),其中有HepB接种史人群流行率为8.52%,无接种史人群HBsAg流行率为18.15%.对HBsAg阳性及阴性者进行病例对照研究,结果显示HepB对各年龄组HBV感染都有保护作用,总保护率为62.6%.结论非新生儿人群接种HepB对乙肝病毒感染有一定的保护效果. |
| 英文摘要: |
| Objective To study the immunization coverage and immune effects ofhepatitis B vaccine(HepB)among people who were immunized later than at birth in Guangzhou eity．Methods A multistage randomized cluster sampling was used and the subjects were at age 20 to 59 years old． from the families of twelve districts in Guangzhou．Cross sectional analysis was carried out．Every study subject'S HepB immunization history and main risk were investigated through questionnaire． Venous blood samples were collected and then tested for HBsAg and anti-HBs by means of ELlSA． The immnnization coverage rate of HepB．prcvalence rates of HBsAg and anti-HBS among every age group were valuated by sampling weights．The protective efficacy of the people with immunization of HepB WaS assessed by case-controI study．Results The overall immunization rate of HepB was 24．7l％(95％CI：20．86％一28．56％)in the 20—59 age group．HBsAg prevalence rate Was 14．91％ (95％C/：12．73％一17．08％)，and 8．52％in vaccinated group while 18．15％in the non．vaccinated group.Results from case．conffoI study showed that HepB had good protective efficacy to HBV in people of 20—59 years old．The protective rate of HepB against HBV was 62．6％．Conclusion Vaccinating HepB on people aRer the neonatal period also non．nowbom could provide good inuTlune effect to HBV |
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