文章摘要
李佳萌,张颖,高璐,刘辉,李力,吕莉琨,杨东靖.天津市2009——2010年健康人群肠道病毒71型中和抗体血清流行病学调查[J].中华流行病学杂志,2011,32(6):568-570
天津市2009——2010年健康人群肠道病毒71型中和抗体血清流行病学调查
Seroepidemiology investigation of neutralizing antibody against enterovirus 71 among healthy people in Tianjin
收稿日期:2011-02-16  出版日期:2014-09-10
DOI:
中文关键词: 肠道病毒71型;中和抗体;健康人群;血清流行病学
英文关键词: Enterovirus71;Neutralizing antibody;Healthy people;Seroepidemiology
基金项目:
作者单位E-mail
李佳萌 天津市疾病预防控制中心, 300011 jiamengli2005@yahoo.com.cn 
张颖 天津市疾病预防控制中心, 300011  
高璐 天津市疾病预防控制中心, 300011  
刘辉 天津市疾病预防控制中心, 300011  
李力 天津市疾病预防控制中心, 300011  
吕莉琨 天津市疾病预防控制中心, 300011  
杨东靖 天津市疾病预防控制中心, 300011  
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中文摘要:
      目的 调查天津市健康人群肠道病毒71型(EV71)隐性感染状况.方法 采集1611名天津市健康人静脉血标本进行EV71中和抗体测定,对检测结果进行分析.结果 以抗体滴度1:4作为临界值,调查对象EV71中和抗体阳性率为66 79%(1076/1611),0~5岁年龄组的抗体阳性率最低为32 71%,16~25岁年龄组的抗体阳性率最高为76.67%,不同年龄组的抗体阳性率差异有统计学意义.市内六区EV71的抗体阳性率最低为59.05%,远郊五县的抗体阳性率最高为72 35%;不同区域间的抗体阳性率差异有统计学意义.EV71抗体滴度≥1:256的人数占5.71%.经logistic回归分析,年龄、流动人口数量和区域都是影响EV71抗体阳性率的因素.结论 年龄的增长增加了EV71隐性感染的机会,但抗体水平不可能持久保持;流动人口较多、卫生条件差的地区应作为手足口病防控的重点.
英文摘要:
      Objective To investigate the latent infection caused by enterovirus 71 (EV71) among healthy people in Tianjin and to provide evidence on prevention and control hand-food and mouth diseases (HFMD). Methods 1611 sera specimens were collected from healthy people in Tianjin while EV71 antibody was detected by neutralization test, and then the results were analyzed statistically. Results For determining positivity, the cut-point was set at 1:4. The positive rate was 66.79%( 1076/1611) for EV71 neutralizing antibody. The lowest positive rate was 32.71% in the 0-5 age group while the highest rate was 76.67% in the 16-25 age group. Significant difference was seen in the positive rates among different age groups. The lowest positive rate (59.05%) was seen in the city areas while the highest rate (72.35%) was seen in the surrounding counties. 5.71% of the people being tested showed their neutralizing antibody as ≥1:256. The difference was statistically significant on positive rates among different areas. We constructed logistic regression models with the EV71 neutralizing antibody positive rate as the dependent variable and age, sex, floating population, area etc. as independent variables. There appeared statistical significances in all the independent variables. Conclusion Age seemed a risk factor for recessive infection of EV71, and the neutralizing antibody against EV71 might not be kept permanently. In order to prevent and control the HFMD, more attention should be paid to the areas where more floating population were resided.
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