| 阮峰,谭爱军,张雪宝,陈雪琴,萧松健,叶中文,王松.手足口病重症病例临床特征的Fisher逐步判别分析[J].中华流行病学杂志,2011,32(7):716-719 |
| 手足口病重症病例临床特征的Fisher逐步判别分析 |
| Step Fisher discriminant analysis on severe clinical features of hand foot and mouth disease between enteroviells {EV}71 and other EV |
| 收稿日期:2011-01-28 出版日期:2014-09-10 |
| DOI： |
| 中文关键词: 手足口病 重症病例 临床特征 判别分析 |
| 英文关键词: foot and mouth disease Severe EV71 CIinical feature Discriminantanalysis |
| 基金项目: |
| 作者 | 单位 | E-mail | | 阮峰 | 519002 广东省, 珠海市, 疾病预防控制中心 | | | 谭爱军 | 519002 广东省, 珠海市, 疾病预防控制中心 | zhcdc@sina．com | | 张雪宝 | 519002 广东省, 珠海市, 疾病预防控制中心 | | | 陈雪琴 | 519002 广东省, 珠海市, 疾病预防控制中心 | | | 萧松健 | 519002 广东省, 珠海市, 疾病预防控制中心 | | | 叶中文 | 519002 广东省, 珠海市, 疾病预防控制中心 | | | 王松 | 519002 广东省, 珠海市, 疾病预防控制中心 | |
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| 中文摘要: |
| 目的比较肠道病毒(EV)71型(EV71)与其他EV感染手足口病重症病例的临床特征，寻找EV71手足口病重症病例的特异性诊断指标。方法病例定义采用卫生部“手足口病诊疗指南(2010年版)”，通过查阅病历及现场个案调查，获得定点收治医院手足口病重症病例的临床资料．PCR检测粪便标本中EV、EV71及CoxAl6等核酸。比较EV71与其他EV感染的手足口病重症病例临床特征。有统计学意义的指标进行Fisher逐步判别分析。结果EV71与其他EV感染的手足口病重症病例比较，肢体抖动、易惊、精神差、抽搐等神经系统症状和体征以及脑脊液白细胞计数升高等指标的差异有统计学意义(P结论肢体抖动和脑脊液白细胞计数升高可作为EV7i重症病例的判别诊断指标。 |
| 英文摘要: |
| 0bjective To compare the clinical features ofsevere hand foot and mouth disease between enterovirus(EV)71 and other EV to find specific diagnosis index of EV71 severe hand foot and mouth disease．Methods Case definition were adopted from national guideline of hand foot and mouth disease diagnose(Version 20 l 0)．Clinical data of severe hand foot and mouth disease came from case history and contents of questionnaire would include the ones between the time of onset and diagnoses being made．EV and EV7l，COX A1 6 nucleic acid tested were bV RT-PCR in stool samples．Clinical features of severe hand foot and mouth disease between EV7 l and other EV were compare．Results There appeared statistical differences between neurologic symptoms such as tremor，myoclonic ierk，Iistlessness，convulsion and white blood cell counts in CSF(P<0．05)．Results from the step Fisher diseriminant analysis showed only tremor and white blood cell had an increase in CSF．with statistically significant differences．The discriminant equation of EV7l was Y=3．059XX1+3．83XX5一2．742 and the equation of other EV was Y=1．634X1+1．623X5一1．693．The specificity of EV7l Was 9 l％and the specificity of other EV Was 40％．Conclusion The increase of clinical features oftremor and white blood cell in CSF could be used as diagnosis index ofsevere EV71． |
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