文章摘要
韦所苏,邹云锋,徐永芳,刘金纪,农全兴,白玉,石艺,钟晓妮,黄文祥,梁浩,黄爱龙.广西地区650 名男男性行为者对暴露前预防HIV感染接受意愿及其影响因素研究[J].中华流行病学杂志,2011,32(8):786-788
广西地区650 名男男性行为者对暴露前预防HIV感染接受意愿及其影响因素研究
Acceptability and influencing factors of pre-exposure prophylaxis among men who have sex with men in Guangxi
收稿日期:2011-03-03  出版日期:2014-09-17
DOI:
中文关键词: 艾滋病病毒  男男性行为者  暴露前预防  接受意愿
英文关键词: Human immunodeficiency virus  Men who have sex with men  Pre-exposure prophylaxis  Acceptability
基金项目::国家“十一五”科技重大专项(2008ZX10001-016);广西高校人才小高地建设创新团队资助计划(桂教人工[2010]38 号);广西“新世纪十百千人才工程”人选课题(桂人社办发[2010]319 号)
作者单位E-mail
韦所苏 530021 南宁,广西医科大学公共卫生学院(韦所苏、邹云锋、石艺、梁浩)  
邹云锋 530021 南宁,广西医科大学公共卫生学院(韦所苏、邹云锋、石艺、梁浩)  
徐永芳 南宁市疾病预防控制中心(徐永芳、农全兴)  
刘金纪 柳州市疾病预防控制中心(刘金纪、白玉)  
农全兴 南宁市疾病预防控制中心(徐永芳、农全兴)  
白玉 柳州市疾病预防控制中心(刘金纪、白玉)  
石艺 530021 南宁,广西医科大学公共卫生学院(韦所苏、邹云锋、石艺、梁浩)  
钟晓妮 重庆医科大学(钟晓妮、黄文祥、黄爱龙)  
黄文祥 重庆医科大学(钟晓妮、黄文祥、黄爱龙)  
梁浩 530021 南宁,广西医科大学公共卫生学院(韦所苏、邹云锋、石艺、梁浩) Haolphd@163.com 
黄爱龙 重庆医科大学(钟晓妮、黄文祥、黄爱龙) ahuang1964@yahoo.com.cn 
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中文摘要:
      目的<\b>了解广西地区男男性行为者(MSM)对暴露前预防﹙PrEP﹚HIV 感染的接受意愿及其影响因素。方法<\b>采用滚雪球法招募650 名MSM,利用自行设计的调查问卷一对一面访,了解MSM与艾滋病相关的高危行为、对PrEP 的知晓情况及接受意愿。结果<\b>假设PrEP 使用的药物安全、有效且免费提供,有91.9%的MSM表示愿意服用药物。自述愿意服药的原因主要为可降低HIV 感染的风险,不愿意服用药物的原因主要为担心药物的副作用和怀疑药物的效果。logistic 回归分析显示,与接受PrEP 意愿有关的因素为“是否通过朋友介绍性伴”(OR=6.21,P=0.020)、“是否有能力预防HIV 感染”(OR=0.32,P=0.010)、“是否拒绝与不使用安全套的人发生性行为”(OR=0.34,P=0.010)、“是否建议朋友接受PrEP”(OR=39.32,P=0.000)。结论<\b>药物的安全性、有效性及费用可能是影响广西地区MSM接受PrEP 的主要因素,免费提供安全、有效且副作用小的药物可能是推广PrEP 的较好方式;以同伴教育的方式宣传PrEP 可能会提高其接受意愿。
英文摘要:
      Objective To study the acceptability of pre-exposure prophylaxis(PrEP) to prevent the transmission of HIV among men who have sex with men(MSM)in Guangxi,China.Methods Snow-balling methods were used to recruit 650 MSM in Guangxi. Questionnaires and interview were administrated to these 650 men,using a self-designed questionnaire and face to face interviews to collect information on HIV-related risk behaviors,knowledge and acceptability of PrEP.Results After an introduction on PrEP by interviewers,followed by as the statement—‘If PrEP was effective,safe and free of charge',597(91.9%)of the 650 MSM claimed that they would accept it, with the main reason as the recognition of‘PrEP can decrease the risk of HIV infection'. For those who refused to use it,most of them said that were afraid of the side-effect and doubted on the effectiveness of PrEP. Data from logistic regression analysis showed that those who had found partners through friends(OR=6.21,P=0.020)and those who would advise his friend to use PrEP(OR= 39.32,P=0.000)were more likely to accept PrEP. Those who thought they could protect themselves from HIV infection(OR=0.32,P=0.010)or not having sex with the ones who refused to use a condom(OR=0.34,P=0.010)were less likely to accept PrEP.Conclusion Effectiveness,safety and cost seemed to be the main influential factors related to the acceptability of PrEP. Peer education might improve the acceptability of PrEP.
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