文章摘要
张秋,彭浩,丁建松,徐燕英,晁湘琴,田洪刚,张永红.晨尿中微量白蛋白/肌酐比值与中老年女性高血压前期关系的研究[J].中华流行病学杂志,2012,33(1):32-36
晨尿中微量白蛋白/肌酐比值与中老年女性高血压前期关系的研究
Association between urinary albumin-to-creatinine ratio and prehypertension
收稿日期:2011-08-02  出版日期:2014-09-10
DOI:
中文关键词: 高血压  高血压前期  尿微量白蛋白/肌酐比值
英文关键词: Hypertension  Prehypertension  Urinary albumin-to-creatinine ratio
基金项目:
作者单位E-mail
张秋 苏州大学医学部公共卫生学院流行病学教研室 215123
苏州市金阊区疾病预防控制中心 
 
彭浩 苏州大学医学部公共卫生学院流行病学教研室 215123  
丁建松 苏州市金阊区疾病预防控制中心  
徐燕英 苏州市金阊区疾病预防控制中心  
晁湘琴 苏州市金阊区疾病预防控制中心  
田洪刚 苏州市金阊区疾病预防控制中心  
张永红 苏州大学医学部公共卫生学院流行病学教研室 215123 Email:yhzhang@suda.edu.cn 
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中文摘要:
      目的 探讨女性人群晨尿中微量白蛋白/肌酐比值(UACR)与高血压及高血压前期的关联性。方法 以苏州市金阊区1796名女性常住居民为研究对象,测量血压、身高、体重和腰围,调查生活习惯、疾病史等情况,检测血糖、血脂、血尿酸、尿微量白蛋白、尿肌酐,采用有序多分类logistic回归模型,进行UACR水平与血压水平的关联性分析。结果 高血压、高血压前期、血压正常组的UACR水平分别为15.54(7.67~32.53)、9.01 (5.45~18.06)、7.13 (4.60~12.50) mg/g,UACR偏高率依次为27.57%、13.42%、9.61%,三组间的差异均有统计学意义(P<0.05).UACR水平处于1、2、3和4分位者,控制其他混杂因素后,其收缩压分别为125.3、128.8、130.8和135.1 mmHg,舒张压分别为80.9、82.7、84.0和85.9 mm Hg;发生高血压前期或高血压的危险性随着UACR水平的增加而升高,存在着剂量-反应关系;与最低分位者相比,调整了年龄、吸烟、饮酒、高血压家族史、超重、腹型肥胖、高血糖、血脂异常、高尿酸后,UACR水平处于第2、3、4分位者患高血压前期或高血压的危险性分别增加了0.32、0.72和1.37倍。结论 女性人群中UACR水平与高血压和高血压前期相关联。
英文摘要:
      Objective This study was operated to investigate the association between urinary albumin-to-creatinine ratio (UACR) and physical situations as hypertension and prehypertension among women.Methods Blood pressure,height,weight and waist circumference were measured and factors such as cigarette smoking,alcohol intake,family history of hypertension,were investigated.Blood glucose and lipid,serum uric acid,urinary albumin and urinary creatinine were tested on 1796 women aged ≥30 years living in the Jinchang district of Suzhou.Associations between UACR and hypertension as well as prehypertension were analyzed,by using ordinal multinomial logistic regression models.Results The mean levels of UACR were 15.54 (7.67,32.53),9.01 ( 5.45,18.06),7.13 (4.60,12.50 ) mg/g and the rates of higher UACR were 27.57%,13.42%,9.61% in hypertensive,pre-hypertensive and normotensive subjects,respectively,with significant differences noticed among the three groups (P<0.05).The average systolic blood pressure/diastolic blood pressure appeared to be 125.3/80.9,128.8/82.7,130.8/84.0 and 135.1/85.9 mm Hg for participants with UACR in the first,second,third and fourth quartile,respectively.The risks of prehypertension or hypertension increased with increasing UACR levels.Dose-response relationship was seen between UACR and risks of prehypertension or hypertension.Multivariable adjusted odds ratios (95%CI) of prehypertension or hypertension in the upper quartiles of UACR were 1.32 ( 1.02,1.70),1.72 ( 1.32,2.24),and 2.37 (1.80,3.11 ),respectively,when compared with the lowest quartile.Conclusion Elevated UACR was associated with both hypertension and prehypertension among women.
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