文章摘要
文晗,王海俊,董彬,马军.内肥素与儿童青少年肥胖、非酒精性脂肪肝的关联研究[J].中华流行病学杂志,2012,33(3):269-272
内肥素与儿童青少年肥胖、非酒精性脂肪肝的关联研究
Relationship between serum visfatin level and children and adolescent obesity and non-alcoholic fatty liver disease
  
DOI:
中文关键词: 内肥素;肥胖;脂肪肝;儿童
英文关键词: Visfatin;Obesity;Fatty liver;Child
基金项目:教育部博士点基金(200800010067)
作者单位E-mail
文晗 北京大学公共卫生学院/儿童青少年卫生研究所, 100191  
王海俊 北京大学公共卫生学院/儿童青少年卫生研究所, 100191 whjun1@bjmu.edu.cn 
董彬 北京大学公共卫生学院/儿童青少年卫生研究所, 100191  
马军 北京大学公共卫生学院/儿童青少年卫生研究所, 100191 majunt@bjmu.edu.cn 
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中文摘要:
      目的 探讨血清内肥素与儿童青少年肥胖、非酒精性脂肪肝(NAFLD)的关联.方法 采用双抗体夹心ELISA法,测定69名体重正常无NAFLD和106名肥胖儿童青少年(肥胖无NAFLD 49名及合并NAFLD 57名,其中轻度42名、中重度15名)的血清内肥素水平.结果 体重正常组与肥胖组血清内肥素水平分别为( 1.75±0.37)、(1.71±0.37)ng/ml,差异无统计学意义(P=0.455);肥胖儿童青少年血清内肥素水平随着脂肪肝程度的加重而上升[肥胖无NAFLD组为(1.59±0.36)ng/ml、肥胖合并轻度NAFLD组为(1.74±0.36) ng/ml、肥胖合并中重度NAFLD组为( 1.97±0.36)ng/ml,三者之间差异有统计学意义(P<0.05)],与年龄(^β=-0.326,P=0.000)、丙氨酸转氨酶活性(^β=0.286,P=0.004)相关,不同程度NAFLD者内肥素水平差异有统计学意义(^β=0.246,P=0.014).结论 肥胖儿童青少年中血清内肥素水平与NAFLD相关.
英文摘要:
      Objective To examine the relationships between the level of serum visfatin and obesity,nonalcoholic fatty liver disease (NAFLD)in children and adolescents. Methods Serum visfatin levels of 106 obese children/adolescents (including 49 non-NAFLD children and adolescents and 57 NAFLD children/adolescents in which consisting of 42 mild ones,15 moderate-to-severe ones)with another 69 lean children/adolescents as their controls,were examined by indirect sandwich ELISA.Results When comparing the serum visfatin levels,there was no significant difference noticed between the obese group ( 1.71 ± 0.37) ng/ml and the lean group ( 1.75 ± 0.37) ng/ml (P=0.455).With the severity of NAFLD,the serum visfatin level showed an elevation in obese children and adolescents [ obese without NAFLD ( 1.59 ± 0.36) ng/ml,obese with mild NAFLD ( 1.74 ± 0.36) ng/ml,obese with moderate-to-severe NAFLD (1.97 ± 0.36) ng/ml,P<0.05].In the obese group,serum visfatin levels seemed to be related to age (^β=-0.326,P=0.000),alanine aminotransferase (ALT) (^β =0.286,P=0.004) and the degree of NAFLD (^β =0.246,P=0.014).Conclusion The level of serum visfatin was related to non-alcoholic fatty liver in obese children and adolescent.?
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