文章摘要
赵映,田峰,胡舜英,王晶,张弢,陈韵岱,何耀.不同性别冠心病患者危险因素及冠状动脉病变特点分析[J].中华流行病学杂志,2012,33(4):423-427
不同性别冠心病患者危险因素及冠状动脉病变特点分析
Characteristics of traditional risk factors and coronary lesions on coronary heart disease among different sex populations
投稿时间:2011-12-13  
DOI:
中文关键词: 冠状动脉粥样硬化性心脏病;危险因素;性别差异
英文关键词: Coronary heart disease;Risk factors;Gender different
基金项目:北京市自然科学基金(7092099)
作者单位E-mail
赵映 解放军总医院军医进修学院, 北京 100853  
田峰 解放军总医院心内科, 北京 100853  
胡舜英 解放军总医院心内科, 北京 100853  
王晶 解放军总医院心内科, 北京 100853  
张弢 解放军总医院心内科, 北京 100853  
陈韵岱 解放军总医院心内科, 北京 100853 cyundai@medmail.corn 
何耀 解放军总医院老年医学研究所, 北京 100853 yhe301@sina.com 
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中文摘要:
      目的 分析不同性别冠心病(CHD)患者危险因素及其冠状动脉(冠脉)病变的特点.方法 纳入2009年1月至2011年1月在解放军总医院经冠脉造影确诊为CHD患者共3765例(男性2661例,女性1104例),收集患者各类临床资料及冠脉病变数据.根据患者年龄和性别进行分层,应用logistic回归模型分析CHD传统危险因素及冠脉病变的特点.结果 (1)女性发病年龄迟于男性,且合并CHD传统危险因素多;女性随年龄增长,吸烟的比例下降,血脂异常和糖尿病的比例显著升高.男性患者中,吸烟是最常见的危险因素.(2)性别间比较的logistic回归模型提示,糖尿病可显著增加女性罹患CHD的风险(OR=2.05,95%CI:1.49~ 2.81,P<0.001),而吸烟则可明显增加男性罹患CHD的风险(OR=9.27,95%CI:7.68~11.19,P<0.001).(3)随着年龄增长,女性患者冠脉病变支数增加,血管狭窄程度加重;而男性冠脉病变程度无随年龄增长而变化的趋势.结论 不同性别的CHD患者在不同年龄段具有不同的危险因素和冠脉病变特点.糖尿病和血脂异常似对女性冠脉病变的影响较大,而吸烟则对男性影响较大.
英文摘要:
      Objective This study aimed to determine the prevalence rates of conventional risk factors and to analyze the features of coronary lesions in patients with coronary heart disease (CHD).Methods 3765 CHD cases were collected from the General Hospital of PLA in Beijing from 2009 to 2010 (2661 men,1104 women).All the CHD patients enrolled in our study were diagnosed through angiography.Clinical and angiographic data of CHD patients were collected.After stratification on age and sex of the patients,logistic analysis method was used to evaluate the prevalence rates on conventional risk factors and to analyze the features of coronary lesions on CHD.Results ( 1 ) More than two risk factors and advancing age of onset were commonly seen in female CHD patients.In those premature female CHD patients (age <45 years),there was a high proportion the habit of smoking.With the increase of age,proportions of patients with diabetes mellitus and hyperlipidemia also significantly increased.For male patients at different age,the proportions of smoking were high.(2) Data from logistic analysis suggested that diabetes mellitus could increase the prevalence of CHD on women (OR=2.05,95%CI:1.49-2.81,P<0.001),and smoking was a risk factor for men (OR=9.27,95%CI:7.68-11.19,P<0.001).(3) Along with the increase of age,female patients appeared to have more coronary vessel injures or severe coronary artery lesions.Different from the females,there was no change could seen on the characteristics of coronary lesions at different age for males.Conclusion Prevalence rates on risk factors and the characteristics of coronary lesions appeared to be different with age.Diabetes mellitus and hyperlipidemia seemed to impact more on women while smoking seemed to impact more on men.?
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