文章摘要
宋银吟,牟李红,李革,王豫林,肖邦忠,李心术,雷音.现场干预试验中人群尿碘频数的分析[J].中华流行病学杂志,2012,33(5):492-495
现场干预试验中人群尿碘频数的分析
Analysis on the frequency of urinary iodine in a population—based intervention study
收稿日期:2011-11-12  出版日期:2014-11-03
DOI:
中文关键词: 尿碘水平;尿碘频数;社区十预试验;队列人群
英文关键词: rinary iodine level;Urinary iodinefrequency;Community intervention;Cohort
基金项目:重庆市“十一五”科技发展规划重大专项(CSTC,2007AB5034)
作者单位E-mail
宋银吟 医科大学公共卫生与管理学院流行病学教研室, 重庆 400016  
牟李红 医科大学公共卫生与管理学院流行病学教研室, 重庆 400016 mulihong@yahoo.com 
李革 医科大学公共卫生与管理学院流行病学教研室, 重庆 400016  
王豫林 重庆市疾病预防控制中心  
肖邦忠 重庆市疾病预防控制中心  
李心术 重庆市疾病预防控制中心  
雷音 重庆市盐务管理局  
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中文摘要:
      目的分析不同剂量食盐加碘干预后队列人群的尿碘频数,探索较为适宜且安全的碘盐浓度。方法2007--2010年采用多级整群随机抽样方法抽取观察对象,以抽样A、B县的各3个乡镇为单位进行不同食盐加碘浓度[(15--+5)、(25-+5)、(35-+5)mg/kg]的社区干预,随访观察分析干预后队列人群的尿碘频数变化。结果下调浓度后,2县4个试验乡镇人群尿碘中位数随着干预时间逐步降低。A县(15±5)mg/kg和(25±5)mg/kg组儿童尿碘频数主要集中在100~200μg/l和200~300μg/l。B县儿童尿碘频数>300μg/l总体有所下降,100μg/l/L和200~μg/l比例升高,但趋势较为缓慢。4个试验组尿碘频数100—300μg/l的比例较大且保持平稳,始终处于一个较理想的状态;对照组仍以>250。g/L为主。结论建议在重庆市逐步实施分类补碘,在经济较发达地区可将食盐碘浓度从现行的(35±15)mg/kg下调至(25+5)mg/kg,并继续随访其变化。
英文摘要:
      Objective Through a two-year follow up program this study was to analyze the urinary iodine frequency of a cohort in the intervention trial,concerning different doses of saltiodization,SO as to explore the selection of appropriate concentration of salt iodization.Methods A multistage cluster sampling method was used to select three townships in two countries for communi Wintervention with different doses[(15±5)mg/kg,(25±5)mg/kg,(355)mg/kg] ofsaltiodization.Results After intervention,the median of urinary iodine was reduced among the population.The urinary iodine frequencies of (15±5)mg and(25±5)mg/kg among groups of children were mainly concentrated in 100—200μg/L and 200-300μg/L paragraphs in A county.While the300μg/L paragraph had an overall decline in B county,the100μg/Land 200μg/L paragraph ratio increased but the trend seemed to be slow.The 100--300μg/L paragraph of the four treatment groups took alarger proportion and kepts mooth in a more ideal state.However,the control group still maintained at above 250μg/L level.Conclusion The iodine supplementation should be gradually implemented in Chongqing.The doses of salt iodization should be reduced from the current(35±15)mg/kg to(25±5)mg/kgin the economically developed areas.At the same time,we need to continuously follow the changes of the condition.
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