| 宋银吟,牟李红,李革,王豫林,肖邦忠,李心术,雷音.现场干预试验中人群尿碘频数的分析[J].中华流行病学杂志,2012,33(5):492-495 |
| 现场干预试验中人群尿碘频数的分析 |
| Analysis on the frequency of urinary iodine in a population—based intervention study |
| 收稿日期:2011-11-12 出版日期:2014-11-03 |
| DOI： |
| 中文关键词: 尿碘水平 尿碘频数 社区十预试验 队列人群 |
| 英文关键词: rinary iodine level Urinary iodinefrequency Community intervention Cohort |
| 基金项目:重庆市“十一五”科技发展规划重大专项(CSTC，2007AB5034) |
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| 中文摘要: |
| 目的分析不同剂量食盐加碘干预后队列人群的尿碘频数，探索较为适宜且安全的碘盐浓度。方法2007--2010年采用多级整群随机抽样方法抽取观察对象，以抽样A、B县的各3个乡镇为单位进行不同食盐加碘浓度[(15--+5)、(25-+5)、(35-+5)mg／kg]的社区干预，随访观察分析干预后队列人群的尿碘频数变化。结果下调浓度后，2县4个试验乡镇人群尿碘中位数随着干预时间逐步降低。A县(15±5)mg／kg和(25±5)mg／kg组儿童尿碘频数主要集中在100～200μg/l和200～300μg/l。B县儿童尿碘频数>300μg/l总体有所下降，100μg/l／L和200～μg/l比例升高，但趋势较为缓慢。4个试验组尿碘频数100—300μg/l的比例较大且保持平稳，始终处于一个较理想的状态；对照组仍以>250。g／L为主。结论建议在重庆市逐步实施分类补碘，在经济较发达地区可将食盐碘浓度从现行的(35±15)mg／kg下调至(25+5)mg／kg，并继续随访其变化。 |
| 英文摘要: |
| Objective Through a two-year follow up program this study was to analyze the urinary iodine frequency of a cohort in the intervention trial,concerning different doses of saltiodization,SO as to explore the selection of appropriate concentration of salt iodization.Methods A multistage cluster sampling method was used to select three townships in two countries for communi Wintervention with different doses[(15±5)mg／kg,(25±5)mg／kg,(355)mg／kg] ofsaltiodization.Results After intervention,the median of urinary iodine was reduced among the population.The urinary iodine frequencies of (15±5)mg and(25±5)mg／kg among groups of children were mainly concentrated in 100—200μg/L and 200-300μg/L paragraphs in A county.While the300μg/L paragraph had an overall decline in B county,the100μg/Land 200μg/L paragraph ratio increased but the trend seemed to be slow.The 100--300μg/L paragraph of the four treatment groups took alarger proportion and kepts mooth in a more ideal state.However,the control group still maintained at above 250μg/L level.Conclusion The iodine supplementation should be gradually implemented in Chongqing.The doses of salt iodization should be reduced from the current(35±15)mg／kg to(25±5)mg/kgin the economically developed areas.At the same time,we need to continuously follow the changes of the condition. |
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