| 陈素良,赵宏儒,张玉琪,赵翠英,李保军,白广义,梁良,陈志强,回延良,王伟,路新利.河北省受供血人群经血传播艾滋病自然史的回顾性队列研究[J].中华流行病学杂志,2012,33(7):658-662 |
| 河北省受供血人群经血传播艾滋病自然史的回顾性队列研究 |
| A retrospective cohort study on the natural history of AIDS caused by blood transfusion |
| 收稿日期:2012-02-02 出版日期:2014-09-09 |
| DOI： |
| 中文关键词: 艾滋病病毒 有偿供血者 受血者 自然史 |
| 英文关键词: HIV Former commercial plasma donors Blood recipients Natural history |
| 基金项目:河北省科技支撑计划(11276103D-11) |
| 作者 | 单位 | E-mail | | 陈素良 | 河北省疾病预防控制中心, 石家庄 050021 | chensuliang@sina.com | | 赵宏儒 | 河北省疾病预防控制中心, 石家庄 050021 | | | 张玉琪 | 河北省疾病预防控制中心, 石家庄 050021 | | | 赵翠英 | 河北省疾病预防控制中心, 石家庄 050021 | | | 李保军 | 河北省疾病预防控制中心, 石家庄 050021 | | | 白广义 | 河北省疾病预防控制中心, 石家庄 050021 | | | 梁良 | 河北省疾病预防控制中心, 石家庄 050021 | | | 陈志强 | 河北省疾病预防控制中心, 石家庄 050021 | | | 回延良 | 河北省疾病预防控制中心, 石家庄 050021 | | | 王伟 | 河北省疾病预防控制中心, 石家庄 050021 | | | 路新利 | 河北省疾病预防控制中心, 石家庄 050021 | |
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| 中文摘要: |
| 目的 分析经血感染HIV后的潜伏期和生存期.方法 病例来自河北省籍的受血和有偿供血HIV感染者(包括1995年前后发生的一次性受血后HIV感染者和1995年有偿供血者普查发现的HIV感染者).潜伏期研究对象为354例HIV感染者(142例供血感染和212例受血感染),均在发病前无抗病毒治疗(HAART)史；生存期研究对象为141例艾滋病患者(57例供血感染和84例受血感染),均在发病前后无HAART史,动态观察发病和病后死亡情况.结果 截止2010年12月31日,潜伏期观察组HIV感染者累积患病率为88.70％(314/354),发病强度为9.14/100人年(314/3435.75),中位潜伏期为113个月.供血感染观察组142例,中位潜伏期为112个月；受血感染观察组212例,中位潜伏期为115个月.在生存期观察组,141例于病后34个月内全部死亡,病死强度为204.70/100人年(141/68.88),中位生存期为4个月,其中57例供血感染者在发病后24个月内全部死亡,病死强度为250.66/100人年(57/22.74),中位生存期为3个月；84例受血感染者在发病后34个月内全部死亡,病死强度为182.05/100人年(84/46.14),中位生存期为4个月.结论研究中获得了经血传播艾滋病的自然史,对1995年前后有偿供血和受血感染HIV疫情评估具有指导意义. |
| 英文摘要: |
| Objective To study the natural history of AIDS,caused by blood transfusion.Methods All HIV infections and AIDS patients were from Hebei province,including those infected through blood transfusion around 1995,that were identified as through general census of former commercial plasma donors (FCPDs).Among those objects being observed during the incubation period,354 had HIV infections( including 142 cases infected via plasmapheresis and 212 cases caused by transfusion) but had not been treated by HAART before the onset of disease.Objects being observed during the survival period,141 were AIDS patients (including 57 cases infected via plasmapheresis and 84 cases causes by transfusion) but had not been treated by HAART before and after the onset of disease.All infectors and AIDS patients were under follow-up on the progress of illness or death,respectively.Results By December 31,2010,the cumulative incidence among HIV infections was 88.70％ ( 314/354),with the incidence density as 9.14/100 person-years ( 314/3435.75 )and the median incubation period was 113 months.Of 142 HIV infections in the blood donation group and 212 infections in the blood transfusion group,the incubation periods were 112 months and 115 months,respectively.All of the 141 patients died 34 months after the onset,with the death-strength as 204.70/100 person-years (141/68.88) and the period of survival was 4 months.Among those 57 FCPDs infections,they were all died 24 months after the onset,with the death-strength as 250.66/100 person-years (57/22.74) and the survival was 3 months.The other 84 infections who were blood recipients,all died 34 months after the onset,with the death-strength as 182.05/100 person-years (84/ 46.14) and the survival was 4 months.Conclusion Through this study,we noticed that the natural history of all the AIDS patients was caused by blood transmission.It was important to evaluate the natural history of HIV epidemics among both FCPDs and blood recipients,occurred before and after 1995. |
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