文章摘要
李东亮,高彦杰,于明润,杨雪盈,李书明,徐杰,刘英杰,姜树林,张政,肖冬,闫莉,姜桂艳,王红萍,周振海,阮玉华,邵一鸣,罗凤基.北京市男男性行为者HIV新发感染率及影响因素研究[J].中华流行病学杂志,2012,33(7):663-666
北京市男男性行为者HIV新发感染率及影响因素研究
Study on the incidence of HIV and associated risk factors through a prospective cohort among men who have sex with men in Beijing, China
投稿时间:2012-02-01  
DOI:
中文关键词: 男男性行为者;艾滋病病毒;新发感染率;影响因素
英文关键词: Men who have sex with men;HIV;Incidence;Influencing factors
基金项目:国家科技重大专项(2009ZX10004-903,2008ZX10001-016);NIH-NSF合作项目(81161120428);加拿大国际发展署项目(104519-010)
作者单位E-mail
李东亮 北京市朝阳区疾病预防控制中心, 100021  
高彦杰 北京市朝阳区疾病预防控制中心, 100021  
于明润 山东省泰州市疾病预防控制中心  
杨雪盈 北京市朝阳区疾病预防控制中心, 100021  
李书明 北京市朝阳区疾病预防控制中心, 100021  
徐杰 山东省泰州市疾病预防控制中心  
刘英杰 北京市朝阳区疾病预防控制中心, 100021  
姜树林 北京市朝阳区疾病预防控制中心, 100021  
张政 北京市朝阳区疾病预防控制中心, 100021  
肖冬 朝阳华人AIDS干预工作组  
闫莉 北京京城皮肤病医院  
姜桂艳 北京京城皮肤病医院  
王红萍 江苏省丹阳市司徒镇卫生院  
周振海 中国疾病预防控制中心  
阮玉华 中国疾病预防控制中心  
邵一鸣 中国疾病预防控制中心  
罗凤基 北京市朝阳区疾病预防控制中心, 100021 luofengji@yahoo.com.cn 
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中文摘要:
      目的 了解北京市男男性行为者(MSM)HIV血清抗体阳转率的动态变化情况及影响因素.方法 2009年8-12月在北京市招募962名MSM,其中809名HIV阴性进入队列,每6个月随访检测HIV抗体,并进行体检和行为学问卷调查.结果 在招募的962名MSM中,HIV感染率为6.34%(61/962).对809名HIV阴性者在第6、12和18个月随访时,队列保持率分别为95.1%(769/809)、85.5%( 692/809)、71.0% (574/809);HIV血清抗体阳转者分别为19、29和17例;HIV新发感染率分别为5.47/100人年、12.37/100人年、6.86/100人年.18个月随访期间的HIV新发感染率为7.59/100人年.多因素Cox回归模型分析显示,年龄≤25岁(HR=2.32,95%CI:1.39 ~3.87)、认识圈内的朋友数>8个(HR=2.50,95%CI:1.49~4.20)、月经济收入<2000元(HR=1.76,95%CI:1.06~2.95)、最近6个月男男性行为人数>4人(HR=3.50,95%CI:2.11 ~5.81)、体检包皮为包茎或包皮过长或较长者(HR=2.47,95%CI:1.50~4.07)和梅毒检测结果阳性(HR=2.62,95%CI:1.53~4.49)同HIV新发感染的差异有统计学意义.结论 北京市MSM中HIV新发感染率较高,提示该人群中HIV在快速传播.
英文摘要:
      Objective To investigate the dynamic change and associated risk factors of HIV sero-conversion rate in Beijing.Methods 809 sero-negative men who have sex with men (MSM) were recruited in the cohort from August to December in 2009.HIV sero-antibody,medicinal examination and behavior questionnaire interview were carried out every six months.Results 962 MSM with overall baseline prevalence of HIV infection as 6.34% (61/962) together with 809 seronegative MSM,were enrolled in the cohort.Of the 809 sero-negative participants,95.1% (769/809),85.5% ( 692/809 ) and 71.0% ( 574/809 ) of them were retained in the 6-month,12-month and 18- month follow-up visits,with 19,29 and 17 of them became HIV sero-conversion at 6-month,12-month,and 18-month follow-up visits and the HIV incidence rates appeared to be 5.47,12.37 and 6.86 per 100 person-years respectively.The HIV incidence was 7.59 per 100 person-years in the 18 months follow-up visit.Factors including:younger than 25-years old (HR =2.32,95%CI:1.39-3.87),having more than 8 MSM partners (HR=2.50,95%CI:1.49-4.20),less than RMB 2000 Yuan every month income (HR=1.76,95%CI:1.06-2.95 ),having more than 4 homosexual partners in the last six months (HR=3.50,95% CI:2.11 -5.81 ),showing phimosis and redundant prepuce (HR=2.47,95% CI:1.50-4.07 ) as well as positive syphilis test (HR=2.62,95%CI:1.53-4.49) etc.,were significantly associated with HIV incidence.Conclusion High HIV incidence was shown among MSM in Beijing and had spread fast in this population,calling for more favorable prevention measures to be taken.
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