文章摘要
郭永豪,范军星,王哲,孙定勇,王海峰,李梦雷,刘佳,崔卫国,刘国华,郭万申.河南省一起丙型肝炎疫情的血清学调查和风险因素分析[J].中华流行病学杂志,2012,33(7):722-725
河南省一起丙型肝炎疫情的血清学调查和风险因素分析
Sero-prevalence and associated risk factors on hepatitis C in Maqiao township, Henan province of China
收稿日期:2012-03-01  出版日期:2014-09-09
DOI:
中文关键词: 丙型肝炎;疫情;风险因素
英文关键词: Hepatitis C;Epidemic;Risk factors
基金项目:河南省科技创新人才专项
作者单位E-mail
郭永豪 河南省疾病预防控制中心, 郑州 450016  
范军星 河南省疾病预防控制中心, 郑州 450016  
王哲 河南省疾病预防控制中心, 郑州 450016  
孙定勇 河南省疾病预防控制中心, 郑州 450016  
王海峰 河南省疾病预防控制中心, 郑州 450016  
李梦雷 河南省疾病预防控制中心, 郑州 450016  
刘佳 河南省疾病预防控制中心, 郑州 450016  
崔卫国 河南省疾病预防控制中心, 郑州 450016  
刘国华 河南省疾病预防控制中心, 郑州 450016  
郭万申 河南省疾病预防控制中心, 郑州 450016 guows@hncdc.com.cn 
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中文摘要:
      目的 调查2011年河南省某地一起丙型肝炎(丙肝)疫情的传染源及丙肝病毒(HCV)感染率.方法 在疫情地区选取不同方位的5个村庄,共计5187名居民作为调查对象,通过问卷调查个人信息,每名对象抽取5 ml血样检测抗-HCV,阳性者再采用Real-time PCR检测病毒核酸.结果 5187名调查对象年龄1~97岁,平均48岁,男女比例为1∶1.34.抗-HCV检测显示,HCV感染率平均为2.27%,其中1~9岁人群最低(1.55%),≥50岁年龄组最高(4.93%);各村之间感染率差异显著(0.55%~8.68%).风险因素分析和距离与感染率线性回归分析表明,该次疫情可能与某诊所行医有相关性;多因素分析表明疫情主要传播途径为静脉注射、静脉滴注和内窥镜手术3种途径.结论 该次HCV感染疫情为医源性感染.
英文摘要:
      Objective To describe the prevalence and risk factors of hepatitis C virus (HCV) occurred in Henan province,at the end of 2011.Methods Five villages round Maqiao township,including 5187 residents,were selected for the study.Five-milliliter-blood was drawn from every one of the interviewee.Clinical data including age,gender and anti-HCV antibody was recorded.Patients with positive antibodies against HCV were tested for HCV RNA.Results A total number of 5187 people from five villages were studied,with age span from 1 to 97.The average age was 48 years and the sex ratio was 1 ∶ 1.34.The anti-HCV result showed that the prevalence was 2.27%,with 1-9 age group the lowest ( 1.55% ) and the ≥50 year-olds the highest (4.93%).Different villages seemed to have significant differences on the prevalence of HCV,with the highest as 8.68% and the lowest as 0.55%.Under risk factors analysis and distance-infection rates linear regression analysis,data showed that the prevalence might have correlated to the behavior of a certain family-run clinic.Results from multivariate analysis indicated that factors as intravenous dropping,intravenous injection and the use of surgery/endoscope were associated with the HCV infection in this village.Conclusion Although the public health care system had been developed for more than ten years,iatrogenic infection was yet responsible for the infection of HCV patients in the rural areas of China that called for further attention paid to the system.
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