文章摘要
裴华颖,张雨,傅淑霞,杨林,张丽萍.2874例肾病患者病理类型及其临床特征分析[J].中华流行病学杂志,2012,33(8):850-853
2874例肾病患者病理类型及其临床特征分析
CHinical and histo-pathological characteristics of 2874 cases with chronic kidney mseases in Southem parts of Hebei province
收稿日期:2012-02-01  出版日期:2014-09-03
DOI:
中文关键词: 肾脏疾病  病理组织学  临床特征
英文关键词: [Key words] Kidney diseases  Histopatbology  Clinical characteristic
基金项目:
作者单位E-mail
裴华颖 河北医科大学第二医院肾内科, 石家庄 050000 phuaying@gmail.com 
张雨 河北医科大学第二医院肾内科, 石家庄 050000  
傅淑霞 河北医科大学第二医院肾内科, 石家庄 050000  
杨林 河北医科大学第二医院肾内科, 石家庄 050000  
张丽萍 河北医科大学第二医院肾内科, 石家庄 050000  
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中文摘要:
      目的了解河北省南部地区慢性肾病病理类型及其临床特征。方法回顾性分析2008年1月至2011年5月2874例因肾病而行肾活检患者的病理类型和临床特征,并与5年前资料对比。结果2874例患者年龄16~84岁,其中20~50岁者占62.39%,男女比例为1.23:1。原发性肾小球肾炎1966例(68.41%),继发性肾小球肾炎826例(28.74%),肾小管一间质病变79例(2.75%),遗传性疾病3例。原发性肾小球肾炎中最常见病理类型依次为]gA肾病(IgAN)、膜性肾病(MN)和微小病变肾病(MCD);与5年前资料比较:IgAN所占比例略有下降(24.70%埘。26.00%),MN比例升高(16,84%慨10.80%),MCD比例略有上升(15.73%。13.20%)。继发性肾小球肾炎中以紫癜性肾炎(HSPN)和狼疮性肾病(LN)较常见。与5年前资料比较均有所下降(分别为5.50%似。7.00%,6.65%憾6.80%),而HBV相关性肾炎(HBV-GN)所占比例显著升高(4.41% 0.96%)。50岁以上肾病患者的最常见病理类型依次为MN、IgAN、MCD。结论慢性肾病以原发性肾小球肾炎居多。IgAN仍是最为常见的肾小球疾病,且与5年前资料相比,MN、MCD和HBV-GN患者比例均有升高。
英文摘要:
      Objective The aim of tllis study was to analyze the eharactcristics of patientsChnth chronic 16dney disease(CKD)in Southern parts of Hebei province.Methods Records of 2874 CKD patients during January,2008 to May,2011 were retrospectively reviewed.Demographic,elinieal and histo-patllologieal data Were analyzed and compared to ones from the past five years.Results ne age distribution of the groups was between 16 and 84 years old,with 62.39%of them between 20 and 50.An pafients underwent renal biopsy that with primary glomemlonephritis occurring in 1966 cases(68.4l%).secondary glomerulonephritis in 826 cases(28.74%).The frequently s彻pathological patterns WCI"e IgA nephropaty(19AN),membranous nephropathy(MN) and minimal change disease(MCD)in proper order in the former group while Henoch—Schordein purpura nephritis(HSPN)and lupus nephritis(LN)werc scen in the latter group.Comparing to data of the past five years.tIle incidence rates of MN,MCD and HBV-GN increased to 1 6.84%,l 5.73% and 4.4I%respectively.but all IgAN,HSPN and LN had respectively decreased tO 24.70%,5.50% and 6.65%.MN.19AN.MCD were commonly appeared irt histo-pathological patterns among pauents over 50 years of age.Conclusion IgAN was still the most commonly seell renal disease.Compared D dam of the past five years.the incidence rates of MN.MCD and HBV-GN showedineasc at different levels.Epidemiological and pathological pattern of patienb with CKD in Southern Hebei provmce had only mild changes OVer the last 3 years.
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