文章摘要
李玉艳,武俊青,余金明,戎芬,任静朝,高尔生,李春英,华芹,卢斐杰.高出生体重对儿童期血压影响的队列研究[J].中华流行病学杂志,2012,33(12):1213-1217
高出生体重对儿童期血压影响的队列研究
The influence of high birth weight on the blood pressure during childhood—a cohort study
收稿日期:2012-06-12  出版日期:2014-09-18
DOI:10.3760/cma.j.issn.0254-6450.2012.12.003
中文关键词: 高出生体重;血压;队列研究
英文关键词: High birth weight;Blood pressure;Cohort study
基金项目:国家自然科学基金(81072364)
作者单位E-mail
李玉艳 复旦大学公共卫生学院,上海 200032
上海市计划生育科学研究所 
 
武俊青 上海市计划生育科学研究所 wujq16A@yahoo.com.cn 
余金明 复旦大学公共卫生学院,上海 200032  
戎芬 上海市计划生育科学研究所
上海中医药大学 
 
任静朝 复旦大学公共卫生学院,上海 200032
上海市计划生育科学研究所 
 
高尔生 上海中医药大学  
李春英 江苏省江阴市妇幼保健所  
华芹 江苏省无锡市惠山区妇幼保健所  
卢斐杰 锡山区妇幼保健所  
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中文摘要:
      目的 探讨高出生体重对儿童期血压的影响。方法对无锡市1993—1995年建立的高出生体重(暴露组)队列于2005-2007年进行随访,每个暴露对象按“出生日期±2个月”、“性别”匹配一个非暴露(正常体重儿)。共随访到1435对研究对象,对其进行问卷调查,测量身高、体重、血压。结果 高出生体重组的收缩压中位数为100mmHg(Q1一Q3:90—110lnmHg),舒张压为64nlnlHg(Q1~Q3:60一70mlTlHg);正常体重儿组的收缩压为100inn]Hg(Q1~Q,:90—108 rnrnHg),舒张压为62mmHg(Q1~Q,:60。70i/lmHg),两组相比差异均无统计学意义。暴露组“血压升高”(高血压前期和高血压)的比例为13.66%非暴露组为11.57%(P=0.055)。调整儿童期体重指数、性别、儿童随访时年龄、母亲生育年龄、孕龄、婴儿喂养方式、儿童期是否有挑食习惯、儿童期运动时间的多因素二项式回归模型显示,高出生体重导致血压升高的RR值为1.06(0.92~1.21),未达到统计学显著水平。结论 未发现高出生体重与儿童期血压有显著关联。
英文摘要:
      Objective To explore the effects of high birth weight(HBw)on blood pressure (BP)during childhood.Methods A total of 1435 couples with high or normal birth weight were selected from a birth cohort who were born between 1993 and 1995 in wuxi,China and.followed between 2005 and 2007.A questionnaire survey was conducted。with their height,weight and blood pressure measured.Results The medians of systolic blood pressure(SBP)and diastolic BP(DBP) ofHBWgroupwere 100ITlInHg(Q,-Q3:90-110i/iraHg),64111113Hg(Q,-Q3:60—70mmHg)inthe high birth weight group,respectively,while they were 1 00 mn'l Hg(QI.Q3:90—1 08 mm Hg),62 mill Hg(QI—Q3:60-70 nlnl Hg)in the normal weight group.No statistical significant difference was found between the exposed and unexposed groups.The proportion of elevated BP,including prehypertension and hypertension,in exposed group was 1 3.66%,a bit higher than that(11.57%)of the unexposed group(JP=0.055)。The relative risk(RR) ofHBW on elevated BP was 1.06(0。92—1.21), after adjusted the following parameters as BMI in childhood,sex。age during the follow—up period,age of mother at delivery,gestational age,type of feeding at infancy,dietary habit as well as the frequencies of exercise during childhood.Conclusion No statistically significant correlation was found between high birth weight and blood pressure of children.
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