文章摘要
刘萌萌,顾淑君,郭志荣,武鸣,陈秋,周正元,俞浩,丁一,骆文书.PPARα单核苷酸多态性与低高密度脂蛋白胆固醇血症的关联及与PPARγ的交互作用[J].中华流行病学杂志,2012,33(12):1218-1223
PPARα单核苷酸多态性与低高密度脂蛋白胆固醇血症的关联及与PPARγ的交互作用
Association and interacfion of peroxisome proliferator-aetivated receptor α with low high—density lipoprotein hyperlipidemia and with peroxisome proliferator-activated receptor γ
收稿日期:2012-06-23  出版日期:2014-09-18
DOI:10.3760/cma.j.issn.0254-6450.2012.12.004
中文关键词: 低高密度脂蛋白胆固醇血症;过氧化物酶体增殖物激活受体;多态性;交互作用
英文关键词: Low high-density lipoprotein—cholesterol;Peroxisome proliferator-activated receptors;Polymorphism;Interaction
基金项目:卫生部科学研究基金(Wgd2004—2—014)
作者单位E-mail
刘萌萌 苏州大学医学部公共卫生学院流行病与卫生统计学教研室, 215123  
顾淑君 苏州大学医学部公共卫生学院流行病与卫生统计学教研室, 215123  
郭志荣 苏州大学医学部公共卫生学院流行病与卫生统计学教研室, 215123 guozhimn928@163.com 
武鸣 江苏省疾病预防控制中心慢病科 jswuming@vip.sina.com 
陈秋 苏州大学医学部放射生物学教研室  
周正元 江苏省常熟市疾病预防控制中心慢病科  
俞浩 江苏省疾病预防控制中心慢病科  
丁一 苏州大学医学部公共卫生学院流行病与卫生统计学教研室, 215123  
骆文书 苏州大学医学部公共卫生学院流行病与卫生统计学教研室, 215123  
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中文摘要:
      目的 探讨过氧化物酶体增殖物激活受体(PPAR)10个单核苷酸多态性(sNP)以及多个SNP问交互作用与低高密度脂蛋白胆固醇(HDL-C)血症的关联。方法 对820名研究对象进行PPAR 10个SNP多态性检测,以随访时测得的HDL—C值判定低HDL-C血症。运用logistic回归模型分析10个SNP与低HDL.C血症的关联,GMDR模型分析10个SNP的基因一基因交互作用。结果 调整性别、年龄、吸烟、体力活动、高脂饮食和低纤饮食后,与野生型基因携带人群相比,rsl35539突变等位基因携带人群(AC+CC)发生低HDL.C血症的OR=I.46(95%c,:1.07一l 99),rsl800206突变等位基因携带人群(LV+w)发生低HDL-C血症的OR-=O.62(95%C1:O.42一o.90):GMDR模型结果显示,PPARⅡ的rsl35539、rs4253778及PPARy的rsl0865710、rs3856806、rs709158和rs4684847在SNP间的交互作用有统计学意义(P=0.0107)。结论 PPARa的rsl35539多态性与低HDL.C血症有关联,与PPARα的rs4253778和PPARγ的rsl0865710、 rs3856806、rs709158和rs4684847间存在交互作用。
英文摘要:
      Objective To investigate the association of ten single nucleotide polymorphisms (SNPs)in the peroxisome proliferator-activated receptors(α,δ,γ)with low high-density lipoprotein· cholesterol(HDL—C)hyperlipidemia and the additional role of a genc-genc interactions mnong the 10 SNPs.Methods Participants were recruited under the fl'amework of the PMMJS(Prevention of Multiple Metabolic Disorders and MS in Jiangsu Province)cohoa populations survey.in the urban community of Jiangsu province,China.820 s.bjects(579 nolTllaI HDL—C,24 l low HDL·C)were randomly selected.with one of them related to each other.Ten SNPs(rsl35539,r一253778,rsl800206。rs2016520.rS9794,rsl0865710,rs1805192.rs709158,rs3856806,rs4684847)were selected from the HapMap database,which covered PPARa,PPAR8 and PPART.Logistic regression model was used to examine the association between ten SNPs in the PPARs and IOW HDL-C.Odds ratios(OR)and 95%confident interval(95%CI)were calculated.Interactions were expIored by using the method of Generalized Multifactor Dimensionality Reduction(GMDR),Results Alter adjusting the factors as age,Sex,smoking status,occupational physicat activity.high-fat diet as well as low-fiber diet.both rs135539 and rsl800206 were significantly associated witlI the incidence of low HDL-C. witII the OR(95%CI)values as 1.46(1.07—1.99)and 0.62(0.42—0.90).No statistically significant difference was found between other SNPs and the occurrence of 10W HDL.C.Data from GMDR analysis showed significant gene.gene interaction among rsl35539.rs4253778 of PPAR α and rsl0865710,rs3856806,rs709158 and rs4684847 of PPARγ(P=0.0107).Conclusion PPAR α rsl35539 was associated with the occurrence of lOW HDL.C.and had interacted with rs4253778. rsl0865710.rs3856806.rs709158 and rs4684847.
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