| 张婵,单可人,何燕,王婵娟,张婷,李毅,邓婕,李林洁,欧阳凯,官志忠.贵州省侗族、汉族人群乙型肝炎病毒感染结局与趋化因子RANTES基因一403G/A及一2 8C/G位点多态性研究[J].中华流行病学杂志,2012,33(12):1279-1282 |
| 贵州省侗族、汉族人群乙型肝炎病毒感染结局与趋化因子RANTES基因一403G/A及一2 8C/G位点多态性研究 |
| Study on the association between RANTES-403G/A as well as-28C/G gene polymorphism and their susceptibility to the hepatitis B virus infections in Dong and Han ethnicities in Guizhou,China |
| 收稿日期:2012-06-05 出版日期:2014-09-18 |
| DOI：10.3760/cma.j.issn.0254-6450.2012.12.019 |
| 中文关键词: 乙型肝炎病毒 趋化因子RANTES 基因多态性 |
| 英文关键词: Hepatitis B virus Regulated upon activation normal T eell expressed and secreted Gene polymorphism |
| 基金项目:贵州省科技计划(黔科合SY[2010]3001、LG[2011]024) |
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| 中文摘要: |
| 目的 探讨贵州省世居侗族和汉族人群趋化因子RANTES基因(regulated upon activation normal T cell expressed and secreted)-403G/A和-28C/G位点多态性与乙型肝炎病毒(HBV)感染后结局的相关性.方法 采取病例对照方法,募集侗族和汉族共计229例HBV持续感染者、161例HBV清除者作为研究对象,同时选取200例正常者作为对照组.应用TaqMan-MGB探针实时荧光聚合酶链反应SNP分型技术对趋化因子RANTES基因-403G/A和-28C/G位点进行分型测定.结果 趋化因子RANTES基因-403G/A和-28C/G基因型频率在侗族汉族HBV持续感染组、HBV清除组和正常对照组间差异无统计学意义(P＞0.05),单因素分析发现-403AG 和-28GG增加HBV持续感染的危险度(OR＝ 1.292,OR＝1.151).趋化因子RANTES-28C/G基因型频率在侗族和汉族HBV持续感染组分布差异有统计学意义(P＜0.05),而RANTES-403G/A各基因型在两族人群中分布的差异无统计学意义(P＞0.05).结论 携带趋化因子RANTES-403AG和-28GG基因型HBV持续感染风险性高.RANTES-403A有助于HBV清除. |
| 英文摘要: |
| Objective To investigate the association between both regulated upon activation normal T cell expressed and secreted (RANTES)-403G/A,-28C/G gene polymorphism and the susceptibilities to hepatitis B virus (HBV) infection,among people with Dong and Han ethnicities,in Guizhou.Methods A total of 229 individuals with HBV persistence infection,161 HBV clearanced patients and another 200 controls were recruited to conduct a case-control study among residents with Dong or Han ethnicities.Allelic frequencies of both RANTES-403G/A and-28C/G were identified by TaqMan-MGB probe.Results Both RANTES-403G/A and-28C/G polymorphism in the HBV-persistent group,when compared to the HBV-clearances group,no significant difference was found (P＞0.05).Results from the univariate analysis showed that subjects carrying-403AG and-28GG genotype had higher risk on the susceptibility to HBV persistence infection.The distributions of RANTES-28C/G gene polymorphism between Dong minority and Han ethnicities regarding HBV persistence showed statistically significant difference (P＜0.05).There was no difference on the distributions of RANTES-403G/A gene polymorphism between Dong minority and Han ethnicities.Conclusion Patients that carrying both RANTES-403AG and-28GG genotype had higher risk on the persistence to HBV,while RANTES-403A had contributed to the clearance of HBV infection. |
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