文章摘要
张婵,单可人,何燕,王婵娟,张婷,李毅,邓婕,李林洁,欧阳凯,官志忠.贵州省侗族、汉族人群乙型肝炎病毒感染结局与趋化因子RANTES基因一403G/A及一2 8C/G位点多态性研究[J].中华流行病学杂志,2012,33(12):1279-1282
贵州省侗族、汉族人群乙型肝炎病毒感染结局与趋化因子RANTES基因一403G/A及一2 8C/G位点多态性研究
Study on the association between RANTES-403G/A as well as-28C/G gene polymorphism and their susceptibility to the hepatitis B virus infections in Dong and Han ethnicities in Guizhou,China
收稿日期:2012-06-05  出版日期:2014-09-18
DOI:10.3760/cma.j.issn.0254-6450.2012.12.019
中文关键词: 乙型肝炎病毒;趋化因子RANTES;基因多态性
英文关键词: Hepatitis B virus;Regulated upon activation normal T eell expressed and secreted;Gene polymorphism
基金项目:贵州省科技计划(黔科合SY[2010]3001、LG[2011]024)
作者单位E-mail
张婵 洛阳市中心医院生殖助孕中心, 471002  
单可人 贵阳医学院分子生物重点实验室 420578427@qq.com 
何燕 贵阳医学院分子生物重点实验室  
王婵娟 贵阳医学院分子生物重点实验室  
张婷 贵阳医学院分子生物重点实验室  
李毅 贵阳医学院分子生物重点实验室  
邓婕 贵阳医学院分子生物重点实验室  
李林洁 贵阳医学院分子生物重点实验室  
欧阳凯 贵阳医学院分子生物重点实验室  
官志忠 贵阳医学院分子生物重点实验室  
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中文摘要:
      目的 探讨贵州省世居侗族和汉族人群趋化因子RANTES基因(regulated upon activation normal T cell expressed and secreted)-403G/A和-28C/G位点多态性与乙型肝炎病毒(HBV)感染后结局的相关性.方法 采取病例对照方法,募集侗族和汉族共计229例HBV持续感染者、161例HBV清除者作为研究对象,同时选取200例正常者作为对照组.应用TaqMan-MGB探针实时荧光聚合酶链反应SNP分型技术对趋化因子RANTES基因-403G/A和-28C/G位点进行分型测定.结果 趋化因子RANTES基因-403G/A和-28C/G基因型频率在侗族汉族HBV持续感染组、HBV清除组和正常对照组间差异无统计学意义(P>0.05),单因素分析发现-403AG 和-28GG增加HBV持续感染的危险度(OR= 1.292,OR=1.151).趋化因子RANTES-28C/G基因型频率在侗族和汉族HBV持续感染组分布差异有统计学意义(P<0.05),而RANTES-403G/A各基因型在两族人群中分布的差异无统计学意义(P>0.05).结论 携带趋化因子RANTES-403AG和-28GG基因型HBV持续感染风险性高.RANTES-403A有助于HBV清除.
英文摘要:
      Objective To investigate the association between both regulated upon activation normal T cell expressed and secreted (RANTES)-403G/A,-28C/G gene polymorphism and the susceptibilities to hepatitis B virus (HBV) infection,among people with Dong and Han ethnicities,in Guizhou.Methods A total of 229 individuals with HBV persistence infection,161 HBV clearanced patients and another 200 controls were recruited to conduct a case-control study among residents with Dong or Han ethnicities.Allelic frequencies of both RANTES-403G/A and-28C/G were identified by TaqMan-MGB probe.Results Both RANTES-403G/A and-28C/G polymorphism in the HBV-persistent group,when compared to the HBV-clearances group,no significant difference was found (P>0.05).Results from the univariate analysis showed that subjects carrying-403AG and-28GG genotype had higher risk on the susceptibility to HBV persistence infection.The distributions of RANTES-28C/G gene polymorphism between Dong minority and Han ethnicities regarding HBV persistence showed statistically significant difference (P<0.05).There was no difference on the distributions of RANTES-403G/A gene polymorphism between Dong minority and Han ethnicities.Conclusion Patients that carrying both RANTES-403AG and-28GG genotype had higher risk on the persistence to HBV,while RANTES-403A had contributed to the clearance of HBV infection.
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