文章摘要
张志勇,侯晓华,解光越,孙晓威,薛玲.老年髋部骨折与骨质疏松的相关性分析[J].中华流行病学杂志,2012,33(12):1293-1295
老年髋部骨折与骨质疏松的相关性分析
Relationship between elderly hip fracture and osteoporosis
收稿日期:2012-09-12  出版日期:2014-09-18
DOI:10.3760/cma.j.issn.0254-6450.2012.12.022
中文关键词: 老年髋部骨折;骨质疏松;骨密度
英文关键词: Elderly hip fracture;Osteoporosis;Bone density
基金项目:山西省自然科学基金资助项月(2008011075-1)
作者单位E-mail
张志勇 唐山市工人医院骨科,063000  
侯晓华 唐山市工人医院骨科,063000  
解光越 唐山市工人医院骨科,063000  
孙晓威 唐山市工人医院骨科,063000  
薛玲 河北联合大学 xuel_heuu@163.com 
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中文摘要:
      目的 探讨老年人髋部骨折与骨质疏松的相关性,并对结果进行验证.方法 选取2009年1月至2012年3月唐山市工人医院收治的85例老年髋部骨折患者(髋部骨折组),测定其骨密度和尿液中生化标志物Ⅰ型胶原羟基末端肽、脱氧吡啶啉浓度,并选取60名非髋部骨折正常对照组进行对照检验.结果 髋部骨折组骨密度显著低于正常对照组(P<0.05),尿液Ⅰ型胶原羟基末端肽、脱氧吡啶啉的含量显著高于正常对照组,验证骨质疏松患者更易发生髋部骨折.结论 老年髋部骨折多发于外伤,但骨密度和尿液Ⅰ型胶原羟基末端肽、脱氧吡啶啉的含量检测表明,骨质疏松是老年髋部骨折一个重要因素.
英文摘要:
      Objective To explore the relationship between elderly hip fracture and osteoporosis.Methods 85 elderly patients with hip fractures were admitted into our hospital from January 2009 to March 2012.Mineral density in bones and the concentration of biochemical markers Ⅰ collagen such as hydroxy terminal peptide (crosslaps) and deoxypyridinoline (DPD) in urine sample of the patients were measured.Another 60 non-hip fracture patients were selected as controls.Results Bone mineral density from the non-hip-fractured group appeared significantly higher than the hip-fractured group (P<0.05),while the concentration of crosslaps and DPD in the urine of patients were significantly higher than the normal control group (P<0.05),suggesting that the patients suffered from osteoporosis were more prone to hip fracture.ConclusionAlthough the hip fracture in the elderly was generally caused by trauma while factors as bone mineral density,concentration of crosslaps and DPD showed that osteoporosis played an important ‘internal’ role on hip fractures in the elderly.Attention should be paid to the elderly people with symptoms of osteoporosis and early treatment provided,to prevent hip fracture in this populaton.
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