| 刘东颖,谢广茹,陈明.71例男性乳腺癌患者临床与预后分析[J].中华流行病学杂志,2013,34(2):187-190 |
| 71例男性乳腺癌患者临床与预后分析 |
| Analysis on the elinical and prognostic features of 71 male patients with breast cancer |
| 收稿日期:2012-11-19 出版日期:2014-08-07 |
| DOI：10.3760/cma.j.issn.0254-6450.2013.02.019 |
| 中文关键词: 乳腺肿瘤 男性 激素受体 人类表皮生长因子受体一2 |
| 英文关键词: Male breast neoplasia Hormone receptor Human epidermal growth factorreceptor-2 |
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| 中文摘要: |
| 目的探讨男性乳腺癌(MBC)患者临床病理特征及其预后。方法回顾性分析天津医科大学附属肿瘤医院2002年3月至2012年3月71例MBC患者的临床病理及生存资料。结果MBC患者年龄43~84(M=62)岁，中位年龄大于同期女性乳腺癌(FBC)患者(t=6．355，P=0．000)，与同期FBC例数之比为o．42%(71：16 796)；MBC病理类型以浸润性导管癌(x2=29．875，P=0．000)、临床分期以>ⅢA(x2=13．377，P=0．037)多见。MBC患者雌激素受体阳性率明显高于FBC患者，而人类表皮生长因子受体-2(HER-2)阳性率明显低于FBC患者x2=3．741，P=0．048；x2=12．845，P-0．002)。单因素和多因素分析发现MBC患者预后比FBC患者差(P-0.004，P=0.046)。MBC患者的HER-2表达水平是影响其预后的重要因素(x2=4．219，P=0．040)。结论MBC与FBC的临床特征及预后均存在显著差异。HER一2阳性可能对MBC的预后及治疗有重要意义。 |
| 英文摘要: |
| Objective Male breast cancer(MBC)iS a rare disease,with clinical and prognostic features still controversial．The aim of this study was to discuss the clinical characteristies
and prognosis of MBC．Methods Clinical data related to 7 l MBC patients was reviewed．Results The radio of MBC to female breast cancer(FBC)was 42：1 0 000．Age related to the diagnosis of MBC ranged from 43 to 84 years with the median age as 62 years old．older than the FBC patients(t=6．355．P=0．000)．The percentage ofinvasive ducal carcinoma in MBC patients was much higher than in FBC patients(X 2=29．875,P=0．000)．The positive rate of estrogen receptor(ER)was significantly higher than those in FBC patients and the positive rates of human epidermal growth factor receptor-2(HER-2)were less frequently(X2=3．741,P=0．048 and X2=12．845,P=0．002) seen．Data from the univariate and multivariate analysis showed that the 3-．5-and 10-year survival rates of MBC were 82．6%．74．O%and 47．4%respectively。significantly higher than those in FBC patients(P=0．004．P=0．046)．Patients with positive HER-2 showed worse prognosis than HER-2
negative patients in MBC patients(X2=4．219,P=0．040)．Conclusion There were significant
clinic-pathologic and prognostic differences between FBC and MBC patients．The HER-2 positivity seemed to be an important factor for the prognosis and treatment of patients with MBC． |
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