文章摘要
黄志征,李瑛,王春,孙涛,李慧乔,孙志明,周健,巴磊,陈同.口服避孕药暴露及血管紧张素基因多态与女性脑卒中发病风险的关联研究[J].中华流行病学杂志,2013,34(4):321-325
口服避孕药暴露及血管紧张素基因多态与女性脑卒中发病风险的关联研究
Study on the association of oral contraceptives, angiotensinogen gene polymorphisms and the risk of stroke in women
收稿日期:2012-10-14  出版日期:2014-09-03
DOI:
中文关键词: 脑卒中;口服避孕药;血管紧张素原;基因多态性;联合作用
英文关键词: Stroke;Oral contraceptives;Angiotensinogen;Gene polymorphism;Joint effect
基金项目:国家自然科学基金(30972542,30571606);国家“十一五”科技支撑计划(2006BAll5807)
作者单位E-mail
黄志征   
李瑛  liyin92008@ismail.com.cn 
王春   
孙涛   
李慧乔   
孙志明   
周健   
巴磊   
陈同   
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中文摘要:
      目的 <\b>探讨口服避孕药(OC)暴露和血管紧张素原(AGT)基因多态及其联合作用与中国女性脑卒中发病风险的关联.方法 <\b>在“女性避孕药和宫内节育器使用队列”随访的基础上前瞻性收集确诊的脑卒中新发病例,采用病例对照研究方法(按年龄和地区匹配健康对照和医院对照),应用实时荧光定量PCR(Taqman)检测其基因型.结果 <\b>(1)OC轻度升高出血型脑卒中发病风险(OR=1.83,95%CI:1.25~ 2.66).(2)A-6G的AG/GG基因型降低脑卒中发病风险(OR=0.78,95%CI:0.61 ~ 0.99);Cl1535A的CA/AA基因型使梗塞型脑卒中风险略有降低(OR=0.62,95%CI:0.45 ~ 0.85),AA基因型则使出血型脑卒中的发病风险升高(OR=2.57,95%CI:1.03~6.42).(3)OC和AGT基因的联合作用使得出血型脑卒中的发病风险略有升高.结论 <\b>AGT基因多态性与中国女性脑卒中的发病有关,OC与AGT基因多态性之间的联合作用可能升高出血型脑卒中的发病风险.
英文摘要:
      Objective <\b>To evaluate the associations of oral contraceptives (OC) exposure,angiotensinogen (AGT) gene polymorphism and joint effects on the risk of stroke in Chinese women.Methods <\b>On the basis of a prospective female cohort of contraceptive use,the first-ever-developed (FED) stroke cases,as well as,two sets of age-(± 3 years) and region-matched controls (including neighborhoods and hospitalized patients) were recruited.Between 1 July 2000 and 30 June 2009,a total of 453 FED stroke cases and 919 controls were recruited.Genotyping for polymorphisms of AGT gene was detected by Taqman method.Results <\b>(1) The risk of stroke gradually increased with the cumulative time of OC use in women (P<0.0001).Compared with the non-users,the risk of hemorrhagic stroke slightly increased among those with OC use (OR=1.83,95%CI:1.25-2.66).(2)Women with AG/GG genotypes of A-6G locus or CA/AA genotypes of Cl1535A locus indicated that there was a slightly reduced risk of stroke (OR=0.78,95% CI:0.61-0.99; OR=0.73,95% CI:0.56-0.95).(3) Women with AA genotypes of A-20C locus and AG/GG genotypes of A-6G,when incorporated with CA/AA genotypes of Cl1535A locus with OC,it could increase the risk of hemorrhagic stroke(OR=1.99,95%CI:1.34-2.97; OR=1.84,95%CI:1.15-2.94; OR=1.73,95%CI:1.06-2.85).Conclusion <\b>The AGT gene polymorphisms showed that they did have an impact on the risk of stroke.And the joint effect between women using OC and AGT gene polymorphisms could slightly increase the risk of stroke.
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