文章摘要
蔡畅,周书进,文师吾,郭亚伟,谭红专,王莎亚,罗美玲,胡丽,何玥.孕前因素对新生儿出生重量指数的影响[J].中华流行病学杂志,2013,34(4):342-345
孕前因素对新生儿出生重量指数的影响
Pre-conceptive factors on the birth ponderal index
收稿日期:2012-10-16  出版日期:2014-09-03
DOI:
中文关键词: 新生儿重量指数;孕前影响因素;队列研究
英文关键词: Birth ponderal index;Pre-conception factors;Cohort study
基金项目:国家自然科学基金(30872167)
作者单位E-mail
蔡畅   
周书进   
文师吾   
郭亚伟   
谭红专  tanhz99@qq.com 
王莎亚   
罗美玲   
胡丽   
何玥   
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中文摘要:
      目的 <\b>探讨新生儿出生重量指数(PI)的孕前影响因素.方法采用前瞻性队列研究方法,通过整群随机抽样,从湖南省浏阳市37个乡镇中随机抽取14个乡镇,自2008年4月始收集所有在妇幼保健机构登记建册,并计划1年内生育且愿意抽血检测的妇女作为研究对象组成孕前队列,随访追踪其妊娠结局.单因素分析采用x2检验和相关分析,多因素分析采用logistic回归分析.结果 <\b>进入队列1368人,其中已怀孕产生单胎活产妊娠结局且资料完整者611人.在611名新生儿中,平均出生体重(3.26±0.43)kg,出生身长(50±0.46)cm,出生PI为26.08±3.43.多因素分析显示,孕前经济收入水平(OR=6.920,95%CI:1.089~43.974)和血清皮质醇水平(OR=5.121,95%CI:0.886~29.611)是低PI新生儿的危险因素;低密度脂蛋白胆固醇(LDL-C)水平(OR=3.736,95%CI:0.848~16.461)和中心性肥胖(OR=6.846,95%CI:1.441~32.532)是高PI新生儿的危险因素;文化程度(OR=0.169,95%CI:0.029 ~ 0.995)和胰岛素水平(OR=0.141,95%CI:0.016~ 1.277)是高PI新生儿的保护因素.结论 <\b>新生儿出生PI与孕前经济收入水平、文化程度、腰围及胰岛素、LDL-C和皮质醇水平有关.育龄妇女在孕前如能检测相关指标,并通过运动、饮食等途径进行调整,可预防非正常PI新生儿的出生.
英文摘要:
      Objective <\b>To analyze the pre-conceptive factors on birth ponderal index (PI).Methods <\b>Fourteen towns were selected randomly from the 37 towns of Liuyang county,Hunan province,through cluster sampling in a prospective cohort study.Information was collected on all the women registered at the Maternity and Child Care Departments,and were planning to give birth in the coming year plus willing to receive a blood test and then followed-up until delivery.Single factor analysis would involve chi-square test and correlation analysis,while the multiple-factor analysis would adopt binary logistic regression method.Results <\b>A total of 1368 women were recruited in the cohort and 611 of them had a delivery of one child.Means of birth weight,birth length,and birth PI were (3.26 ± 0.43) kg,(50± 0.46) cm and 26.08 ± 3.43,respectively.Data from the multiple stepwise regression analysis showed that income (OR=6.920,95% CI:1.089-43.974) and cortisone levels (OR=5.121,95% CI:0.886-29.611) were related to low PI,while LDL-C (OR=3.736,95% CI:0.848-16.461),waistline (OR=6.846,95% CI:1.441-32.532),education (OR=0.169,95% CI:0.029-0.995),and insulin (OR=0.141,95% CI:0.016-1.277) were related to high PI.Conclusion <\b>Birth PI was associated with income,waistline,education,insulin,cortisone,and LDL-C.Before conception,women should go through necessary tests and keep a good physical condition to reduce their neonates of having abnormal PI.
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