文章摘要
陈冀,陈朔华,刘星,张彩凤,姚涛,杨慧,王剑利,吴寿岭.基线心率对中国北方成年人群全因死亡率的影响[J].中华流行病学杂志,2013,34(6):622-625
基线心率对中国北方成年人群全因死亡率的影响
Relationship between baseline heart rate and all-cause death in general population
收稿日期:2013-01-16  出版日期:2014-09-18
DOI:
中文关键词: 心率;全因死亡;队列研究
英文关键词: Heart rate;All-cause death;Cohort study
基金项目:国家自然科学基金(30972433);“十一五”国家科技支撑计划(2007BAcl6807)
作者单位E-mail
陈冀 Convalescent Home of Kailuan General Hospital,Tangshan 063000, China
 
drwusl@163.com 
陈朔华 Kailuan General Hospital
 
 
刘星 Kailuan General Hospital
 
 
张彩凤 Hebei United University
 
 
姚涛 Linxi Hospital of Kailuan General Hospital  
杨慧 Kailuan General Hospital
 
 
王剑利 Kailuan General Hospital
 
 
吴寿岭 Kailuan General Hospital
 
 
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中文摘要:
      目的探讨基线心率水平对人群全因死亡的影响.方法选取参加2006-2007年度开滦集团健康体检有完整心电图资料且心率在40 ~ 120次/分、无心肌梗死和脑卒中病史93 716人为研究对象,研究随访期为2006年7月至2010年12月,平均随访时间(47.5±4.3)个月,随访期间每6个月收集一次全因死亡事件.结果(1)总人群心率60 ~ 69次/分组累积死亡率最低为1.61%;男性心率60~ 69次/分组累积死亡率最低为1.78%;女性心率<50次/分组中没有发生全因死亡事件,80~89次/分组累积死亡率最低为0.60%.(2)Cox风险比例模型结果显示总人群心率70~ 79次/分组、80~ 89次/分组、90 ~ 99次/分组和≥100次/分组发生全因死亡的RR值(95%CI)分别为1.187(1.039 ~ 1.336)、1.392(1.185~1.636)、1.733(1.404 ~ 2.139)和2.716(2.171~3.398),男性人群各心率组发生全因死亡的RR值(95%CI)分别为1.227(1.067 ~ 1.410)、1.481 (1.254~1.750)、1.754(1.406 ~ 2.188)、2.831(2.245~ 3.571),女性人群以心率80~ 89次/分组作为对照组,心率60~ 69次/分组、70~79次/分组和≥100次/分组发生全因死亡的RR值(95%CI)分别为0.671(0.568~ 0.793)、0.825(0.703~ 0.970)、1.925(1.512 ~2.453).结论心率≥70次/分后,随心率增加发生全因死亡事件率增加.心率与发生全因死亡的风险比呈J形曲线关系.
英文摘要:
      Objective To investigate the relationship between baseline heart rate(HR) and all-cause death(ACD) in general population.Methods 93 716 workers with heart rate between 40 bpm/min-120 bpr/min and without histories of stroke were selected from the ‘2006-2007 health examination records' in Kailuan and completed the electrocardiogram exam.Related information were also gathered.These subjects were followed up from July 2006 to December 2010,with the mean time of follow-up as 47.5 ± 4.3 months.During the follow-up period,the occurrence of all-cause death was observed every half a year.Results (1) The lowest cumulative mortality rate was 1.61% in the group with 60-69 bpm/min.The lowest cumulative mortality rate was 1.78% in the group of 60-69 bpr/min in men.There was no death events observed in women with less than 50 bpm/min and the lowest cumulative mortality rate was 0.60% in the group of 80-89 bpm/min in women.(2)Data from Cox proportional hazard regression analysis showed that the RR(95%CI) of cumulative mortality rates in general population were 1.187 (1.039-1.336),1.392 (1.185-1.636),1.733 (1.404-2.139) and 2.716(2.171-3.398) in the groups of 70-79,80-89,90-99 and ≥100 bprn/min,respectively.The RRs (95% CI) of cumulative mortality in men were 1.227 (1.067-1.410),1.481 (1.254-1.750),1.754 (1.406-2.188) and 2.831 (2.245-3.571) respectively.In women,when comparing with the group of 80-89 bpm/min,the RRs (95% CI) of all-cause death were 0.671 (0.568-0.793),0.825 (0.703-0.970) and 1.925 (1.512-2.453) respectively in the groups of 60-69,70-79 and ≥ 100 bpm/min.Conclusion When HR exceeding ≥70 bpm/min,the increase of HR would also increase the rate of ACD.Results of our study also showed a J-shaped curve relation between HR and mortality.
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