文章摘要
焦黏,高菡璐,李航,贾战平,李大鹏,孙冬莹,王滨有.糖尿病前期受高尿酸血症影响的相关因素分析[J].中华流行病学杂志,2013,34(7):725-727
糖尿病前期受高尿酸血症影响的相关因素分析
Pre-diabetes mellitus influeneed by hyperuricemia
收稿日期:  出版日期:2014-09-17
DOI:10.3760/cma.j.issn.0254-6450.2013.07.015
中文关键词: 糖尿病前期;高尿酸血症;稳态模型胰岛素抵抗指数;相关性分析
英文关键词: Hyperuricemia;Homeostasis model assessment-insulin resistance index;Correlation analysis
基金项目:
作者单位E-mail
焦黏 50081 哈尔滨医科大学公共卫生学院流行病学教研室  
高菡璐 50081 哈尔滨医科大学公共卫生学院流行病学教研室  
李航 50081 哈尔滨医科大学公共卫生学院流行病学教研室  
贾战平 50081 哈尔滨医科大学公共卫生学院流行病学教研室  
李大鹏 50081 哈尔滨医科大学公共卫生学院流行病学教研室  
孙冬莹 50081 哈尔滨医科大学公共卫生学院流行病学教研室  
王滨有 50081 哈尔滨医科大学公共卫生学院流行病学教研室 angbinyou@126.com 
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中文摘要:
      目的探讨高尿酸血症影响糖尿病前期(PDM)的相关因素及其两者的关系。方法在2009年2月至2叭0年2月哈尔滨医科大学附属第二医院未使用噻嗪类药物的20~75岁PDM患者中, 随机抽取157例, 按尿酸水平分为正常尿酸(NuA)组(8l例)和高尿酸(HUA)组(76例), 对两组临床资料应用t检验以及Pearson相关分析进行统计分析, 比较两组间BMI、腰围身高比(WSR)、TC、TG、HDL-C、LDL.C、稳态模型胰岛素抵抗指数(HOMA.IR)、糖化血红蛋白(HbAlc)的差异以及各指标与尿酸的相关性。结果(1)HUA组BMI为(27.74±2.88)kg/m, 2、WSR为(0.55 4-0.41)、TC为(6.61±0.73)mmol/L、TG为(3.944-1.97)mmoI/L、LDL.C为(3.604-0.45)mmol/L、HOMA。IR为(3。09±1。20), 均高于NUA组, 差异有统计学意义(P<0。05);(2)PDM患者的尿酸水平与TG、TC、LDL-C及HOMA-IR呈正相关(分别为r=0.29, r=0.33, r=0.49, r=0.51, P<0.05), 与HbAlc呈负相关(r=-0.30, P<0.05)。结论PDM患者血尿酸水平受BMI、TC、TG、LDL-C、HOMA.IR等因素影响。体内HUA状态与胰岛素抵抗密切相关, 促使PDM患者进展为糖尿病, 并引发血脂代谢紊乱。
英文摘要:
      ObjectiveTo investigate the relationship and the influence between pre-diabetes mellitus(PDM)and hyperuricemia(HUA).Methods157 PDM patients, aged 20 to 75 years old were selected from the Second Clinical Medical College of Harbin Medical University.from 2009February to 20l0 February and were divided into HUA group(76 cases)and NUA group(8l cases).All the patients had not been on thiazide drugs.T-test and Pearson correlation analysis were used to calculate the differences and correlation between uric acid and biochemical indicators.ResultsIn the HUA group, BMlwas(27.74±2.88)kg/m2, waistto height ratio(WSR)was(0.55±0.41), TC was(6.6l±0.73)mmol/L, TG was(3.94±1.97)mmol/L, LDL-C was(3.60±O.45)mm01/L and homeostasis model assessment-insulin resistance index(HOMA-IR)was(3.09±1.20), There were significant differences noticed in BMI, TG, TC, LDL-C, HOMA-IR at higher level in the HUA group than those in the NUA group.Pre-diabetes uric acid levels were positively correlated with TG, TC, LDL-C while HOMA-IR(TG:r=0.29, TC:r=0.33, LDL.C:r=0.49, HOMA.IR:r=0.51, PConclusionThe levels of PDM uric acid might both be related with TC.TG.LDL.C and HOMA-IR.The High level of uric acid status in vivo appeared closely related to HOMA.IR, which could further promote the progress of pre-diabetic patients to diabetes and causing dyslipidemia.Our findings suggested that the levels of pre-diabetes uric acid levels should be under concern.
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