| 黄埔,朱奕奕,胡家瑜,姜晨彦,陈波,张宏,陈健.上海市2006-2012年克雅氏病病例监测[J].中华流行病学杂志,2013,34(9):897-899 |
| 上海市2006-2012年克雅氏病病例监测 |
| Study on patients with Creutzfeldt-Jakob disease in Shanghai, 2006-2012 |
| 收稿日期:2013-05-10 出版日期:2014-09-03 |
| DOI： |
| 中文关键词: 克雅氏病|监测|流行病学特征 |
| 英文关键词: Creutzfeldt-Jakob disease|Surveillance|Epidemiological characteristics |
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| 中文摘要: |
| 目的 了解2006——2012年上海市克雅氏病(CJD)监测病例的检测结果及流行病学特征。方法 分析上海市CJD监测网络中可疑CJD病例的临床和流行病学资料，采集病例脑脊液及血液标本检测14-3-3蛋白和129位氨基酸多态性及PRNP基因突变。应用EpiData 3．0软件建立数据库，使用SPSS 17．0软件分析。结果 2006-2012年上海市发现散发型CJD确诊病例1例，临床诊断病例56例，疑似病例17例；家族遗传型CJD确诊病例l例，临床诊断1例，均为E200K突变。病例分布无季节聚集性，历年报告病例数保持稳定。CJD病例居住地散在分布，但2例家 族遗传型CJD患者住址相近。确诊和临床诊断病例的平均年龄为62岁，大于疑似病例的年龄(56岁)，差异有统计学意义。结论2006-2012年上海市CJD历年发病例数稳定，均以散发型为主，职业分布广泛，确诊和临床诊断病例的平均年龄大于疑似病例。 |
| 英文摘要: |
| 0bjective To describe the epidemiological characteristics of patients with Creutzfeldt-Jakob disease(CJD)in Shanghai from 2006 to 20l2．Methods Clinical and epidemiological information on CJD patients from Shanghai CJD Surveillance Network Was analyzed． Cerebral spinal fluid(CSF)and blood specimens from patients were collected and used for detecting the 14-3-3 protein．and polymorphism of 129 amino acid and mutation of PRNP genes．Data Was processed by EpiData(V3．0)and analyzed by SPSS(V17．0)．Results In totally，one definite CJD patient together with 56 probable and 17 possible sporadic CJD patients were identified．One E200K genetic CJD case was diagnosed and another one was clinically diagnosed．No period-or geographic．related events were observed for these cases，but the houses of the two genetic CJD caseswere close to each other．The mean age of onset of the probable CJD patients Was 62 years old which Was significantly older than that of those possible CJD patients．Conclusion Most of the CJD patients identified in Shanghai were sporadic and the number was stable from 2006 to 2012．The mean age of onset of those probable CJD patients Was older than that ofthe possible CJD patients． |
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