| 陈宗遒,陆剑云,肖新才,刘慧,狄飚,李魁彪,鲁恩洁,罗雷,杨智聪.广州地区2006-2012年人感染H5／H7／H9 亚型禽流感病毒风险监测[J].中华流行病学杂志,2013,34(9):900-905 |
| 广州地区2006-2012年人感染H5／H7／H9 亚型禽流感病毒风险监测 |
| Evaluation on the risks of H5，H7 and H9 avian influenza infections in Guangzhou：using data from the 2006-2012 avian influenza surveillance program |
| 收稿日期:2013-05-10 出版日期:2014-09-03 |
| DOI： |
| 中文关键词: 禽流感，H5／H7／H9亚型|监测|风险评估 |
| 英文关键词: Avian influenza,H5／H7／H9 subtypes|Surveillance|Risk evaluation |
| 基金项目:国家科技重大专项(2012ZXl00004213-005) |
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| 中文摘要: |
| 目的 分析2006-2012年广州市人禽流感监测结果，综合评估人群感染H5、H7、H9(H5／H7／H9)亚型人禽流感病毒的风险。方法 广州市人禽流感监测系统包括职业暴露人群血清流行病学监测、环境标本病原学监测、禽流感疫情应急监测、流感样病例病原学监测、不明原因 肺炎监测和重症肺炎排查5个部分。采用RT-PCR检测环境和呼吸道标本中H5／H7／H9禽流感病毒核酸，血凝抑制试验检测职业人群血清H5／H7／H9抗体。结果 2006-2012年共采集禽鸟职业暴露人群和一般人群血清标本4103份，H5／H7／H9抗体总阳性率为3．82％。其中H5抗体阳性为0．22％，H9抗体阳性率为3．70％，H7抗体阳性率为0。有4份血清标本同时检出H5和H9抗体阳性。职业暴露人群H9阳性率(4．2l％)高于对照人群(2．16％)。共采集外环境标本2028份，其中H5核酸阳性标本55份，阳性率为2．71％；H9核酸阳性标本14份，阳性率为0．69％。有5份标本同时检出H5和H9禽流感病毒核酸阳性，其中菜市场禽类摊点H5禽流感病毒核酸阳性率最高(3．03％，46／1518)，未检出H7禽流感病毒核酸。历年应急监测所排查的高危人群和医学观察密切接触者、流感样病例病原学监测、不明原因肺炎和重症肺炎排查对象均未检出H5／H7／H9禽流感病毒核酸。结论 广州地区涉禽环境中存在H5／H9禽流感病毒污染，以菜市场禽类摊点污染为主，禽类职业暴露人群存在一定的H5／H9禽流感病毒无症状感染者，提示广州地区禽类职业人群存在感染禽流感病毒的风险。 |
| 英文摘要: |
| Objective To analyze the results of avian influenza surveillance program in Guangzhou from 2006 to 2012 and to evaluate the risk of infections wim H5，H7 and H9 subtypes avian influenza viruses．Methods Avian influenza surveillance system in Guangzhou consisted fivecomponents：serum surveillance on occupational population．environmental specimen surveillance of avian influenza virus，avian flu emergency surveillance，influenza viruses surveillance on ILI patientand surveillance on pneumonia of unknown causes．Hemagglutination inhibition test was conducted to detect the antibodies against H5，H7 and H9 while PT-PCR was used to test the nucleic acid of H5，H7 and H9 viruses．Results From 2006 to 2012，4103 serum specimens were collected fromoccupational populations and the overall positive rate of H5／H7／H9 antibodies was 3．82％．The antibody positive rates for H5，H7 and H9 were 0．22％．0．00％and 3．70％respectively．4 serum specimens for H5 and H9 simultaneously showed antibody positive．The positive rate of H9 among occupational populations(4．21％)appeared higher than that from the control population(2．16％)． 2028 specimens were collected from poultry sites and 55 samples found positive for H5 nucleic acid (positive rate：2．71％)，14 samples positive for H9 nucleic acid(positive rate：0．69％)，5 specimens simultaneously positive for H5 and H9 nucleic acids．However，none of the samples showing H7 nucleic acid positive．From 2006 to 20 12．all the tested H5／H7／H9 virus were negative from the respiratory／serum specimens among those close contacts of patients or high risk groups through the avian flu emergency surveillance program，ILI patient influenza virus surveillance programs or pneumonia of unknown causes surveillance program．Conclusion Contamination of H5／H9 avian influenza virus did exist in the poultry sites in Guangzhou．especially in the wet Markets．The H5／H9 avian influenza virus caused asymptomatic infection was proved to be existed within the population exposed to the poultry，suggesting that the poultry occupational population in Guangzhou was under the risk of avian influenza virus infection． |
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