文章摘要
张嘉越,李松明,冷津立,陈佑江,浦涧,李金明,庞飞雄,黄永鸿,农江,岑延增,何辉,李瑞,丽宁,何红艳.广西壮族自治区普遍食盐加碘对甲状腺 疾病谱的影响[J].中华流行病学杂志,2013,34(10):970-974
广西壮族自治区普遍食盐加碘对甲状腺 疾病谱的影响
Changes of the spectrum on thyroid disease after the ten--year implementation of universal salt iodization in Guangxi Zhuang Autonomous Regio
收稿日期:2013-05-27  出版日期:2014-10-08
DOI:10.3760/cma.j issn.0254—6450 2013.10.007
中文关键词: 甲状腺疾病|碘营养|疾病谱
英文关键词: hyroid disease|Iodine nutritio|Spectrum of thyroid diseases
基金项目:广西壮族自治区自然科学基金(0728254)
作者单位E-mail
张嘉越 解放军第三医院普外科, 南宁 530021
 
huangyonghong331@163.com 
李松明 解放军第三医院普外科, 南宁 530021
 
 
冷津立 解放军第三医院普外科, 南宁 530021
 
 
陈佑江 解放军第~八一医院普外
 
 
浦涧 右江民族医学院附属医院普外
 
 
李金明 北海市人民医院普外  
庞飞雄 解放军第三医院普外科, 南宁 530021
 
 
黄永鸿 解放军第三医院普外科, 南宁 530021
 
 
农江 Department of Pathology. No. 303 Hoal ofPL4  
岑延增 解放军第三医院普外科, 南宁 530021
 
 
何辉 解放军第三医院普外科, 南宁 530021
 
 
李瑞 解放军第三医院普外科, 南宁 530021
 
 
丽宁 解放军第三医院普外科, 南宁 530021
 
 
何红艳 
1. 解放军第三医院普外科, 南宁 530021

2. 解放军第~八一医院普外

3. 右江民族医学院附属医院普外

4. 北海市人民医院普外
 
 
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中文摘要:
      目的分析广西壮族自治区实行全民普遍食盐加碘(USI)前后不同碘环境下甲状腺 疾病谱变迁的特点。方法按地理分布特点选取南宁、桂林、百色、北海4城市医院1991--2006年 经手术后病理确诊5998例甲状腺疾病患者的尿碘水平,并检测1000例甲状腺正常人群尿碘水平 作对照,分析USI前后碘环境的改变与甲状腺病谱变迁的相关性。结果USI后,甲状腺患者及对 照组的尿碘水平均较USl前增高,旦甲状腺疾病患者尿碘水平高于对照组(分别为324.3肛班、 238.5斗g/L,P<0.05),其中结节性甲状腺肿、毒性弥漫性甲状腺肿、毒性结节性甲状腺肿、慢性淋 巴细胞性甲状腺炎、甲状腺乳头状癌患者尿碘水平较USI前明显增高(分别为263.8“g/L魄69.75 pg/L、289.7 pg/L粥.228.3¨班、346.8 pg/L VS.268A“g/L、350.3 rtg/L掷.316.2}.tg/L、378.5 p叽VS. 305.8“g觅),而毒性结节性甲状腺肿、甲状腺乳头状癌、慢性淋巴细胞性甲状腺炎的构成比(%)较 USI前增高(分别为7.59诋4.80、5.85 YS.4.02、3.88搬.2A6),但结节性甲状腺肿较USI前下降 (63.56傩.69.75)。结论广西壮族自治区USI后甲状腺疾病谱发生明显变化,碘摄人过量可能是 毒性结节性甲状腺肿、慢性淋巴细胞性甲状腺炎、甲状腺乳头状癌的危险因素。
英文摘要:
      Objective To reveal the relationship between iodine nutrition and the c:hange cpf spectrum on thyroid diseases through comparing the different iodine environments pre.and post-.the universalsalt iodization(usl)campaign.Methads To compare the urinary iodine concentration between 1000 normal people and 5998 patients wiith thyroid disease who had undergone surgical operations,from 4 major cities.including jiodine deficient and rich areas of Guangxi Zhuang Autonomous Region.Results After USl was put iinto practice,the urinary jiodine concentration of patients with thyroid appeared higher than those of normal people(324.3 p238.5,P< 0.05).The urinary iodine concentrations of nodular goiter。Graves disease,toxic nodular goiter. thyroid papillary carcinoma and Hashimoto’S thyroiditis were higher than those before the USl was taken(263.8∥L69.75 p,289.7 I_tg/L US.228.3 I.tg/L,346.8 I.tg/L268.4 p,350.3 I_tg/L. 316.2g/L and 378.5 rtg/L VS.305.8 I_tg/L).The proportions of toxic nodular goiter,thyroid papillary carcinoma and Hashimoto’S thyroiditis appeared as 7.59%US.4.80%。5.85%。4.02%and 3.88%/3S2.46%,all higher than those before the implementation of USI.except the nodular goiter which showed a reduction(63.56%.69.75%).Conclusion The spectrum ofthyroid diseases appeared an obvious change in Guangxi within the last 1 0-year implementation of USI.However,the excessive intake of iodine might serve as a risk factor for toxic nodular goiter,thyroid papillary carcinoma and Hashimoto’S thyroiditis.
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