| 姜雪锦,许光,申丽君,吴静,陈辉,王友洁.先天性消化道畸形影响因素的病例对照研究[J].中华流行病学杂志,2014,35(1):81-84 |
| 先天性消化道畸形影响因素的病例对照研究 |
| Iniluential factors on congenital gastrointestinal malformation：a hospital—based case-control study |
| 收稿日期:2013-07-28 出版日期:2014-09-02 |
| DOI： |
| 中文关键词: 先天性消化道畸形 影响因素 病例对照研究 |
| 英文关键词: Congenital gastrointestinal malformation Influential factors Case—control study |
| 基金项目:国家自然科学基金(81273083) |
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| 中文摘要: |
| 目的探讨先天性消化道畸形发病的影响因素，为预防先天性消化道畸形发病提供参考。方法采用以医院为基础的病例对照研究方法，对2011年4月至2012年8月在湖南省儿童医院住院的120例先天性消化道畸形患儿及同期同科室住院的170例非先天性消化道畸形患儿父母进行问卷调查，数据分析采用SPSS 18.0软件。结果先天性消化道畸形与母亲孕前3个月内或孕期服用药物(OR=3.35，95％CI：1.5l～7.41)、服用叶酸(OR=O.28，95％CI：0.15～0.52)、接触油性漆(OR=5.05，95％C1：1.32～19.29)、接触农药(OR=15.20，95％C1：1.55～148.99)及母亲孕前短期内患儿父亲服用药物(OR=3.70，95％CI：1.13.12.10)、吸烟(OR=2.39，95％CI=1.24～4.62)、饮酒(OR=2.47，95％C1：1.20～5.07)、接触室内清洗剂(OR=16.42，95％c，：1.71—157.92)、接触油性漆(OR=9.92，95％C／：2.66～36.98)有关。结论先天性消化道畸形的发生受多种环境因素影响，其中母亲孕前短期内或孕期服用药物、接触油性漆、接触农药、母亲孕前短期内患儿父亲服用药物、吸烟、饮酒、接触室内清洗剂为危险因素，母亲孕前短期内或孕期服用叶酸为保护因素。 |
| 英文摘要: |
| 0bjective To investigate the influential factors on congenital gastrointestinal malformation and to provide evidences for prevention.Methods A hospital—based case-control studywas conducted among infants with or without congenital gastrointestinal malformation at Children’S hospital of Hunan province.from April 201 l to August 2012.Parents of 120 cases with congenital gastrointestinal malformation and another 1 70 controls were asked to fill in a questionnaire.Data was analyzed using SPSS l 8.0 software.Results Congenital gastrointestinal ma：Iformation Was associated with intakes of maternal medication(OR=3.35.95％CI：1.51—7.41)and folie acid(0尺=0.28，95％CI：0.15—0.52)，exposure to paints(OR=5.05，95％CI：1.32一19.29)and pesticides(OR=15.20，95％C／：1.55—148.99)prior to or during pregnancy，and also associated with medication intake of the father(OR=3.70，95％CI：1.13—12.10)，smoking(OR=2.39，95％CI：1.24—4.62)，drinking alcohol(OR=2.47，95％C／：1.20—5.07)，exposure to the agents for indoor cleaning(OR=16.42，95％C7：1.71—157.92)and exposale to paints(OR=9.92，95％C／：2.66—36.98)before conception.Conclusion Congenital gastrointestinal malformation was affected by multiple factors.Potential risk factors for congenital gastrointestinal malformation would include intakes of medication by the pregnant mother，exposure to paints exposure and pesticide exposure before or during pregnancy，andmedication intake by the father，smoking，drinking alcohol，exposure to indoor cleaning agents／paint before conception.The amount of folic acid intake by mother before or during pregnancy was likely to reduce the risk for congenital gastrointestinal malformation. |
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