文章摘要
郭汝宁,彭志强,宋铁,何剑峰,钟豪杰,李灵辉,梁文佳.广东省1990--2012年登革热和基孔肯雅热感染状况及流行风险分析[J].中华流行病学杂志,2014,35(2):167-169
广东省1990--2012年登革热和基孔肯雅热感染状况及流行风险分析
Current infection status and epidemic risk analysis of Dengue fever and Chikungunya in Guangdong province, from 1990 to 2012
收稿日期:2013-09-22  出版日期:2014-09-17
DOI:10.3760/cma.j.issn.0254-6450.2014.02.014
中文关键词: 登革热;基孔肯雅热;感染状况
英文关键词: Dengue;Chikungunya;Infection
基金项目:广东省卫生厅医学科研指令性课题(C2012017)
作者单位E-mail
郭汝宁 广东省疾病预防控制中心公共卫生应急部, 511430, 广州 Email:guogreen@163.com 
彭志强 广东省疾病预防控制中心公共卫生应急部, 511430, 广州  
宋铁 广东省疾病预防控制中心公共卫生应急部, 511430, 广州  
何剑峰 广东省疾病预防控制中心公共卫生应急部, 511430, 广州  
钟豪杰 广东省疾病预防控制中心公共卫生应急部, 511430, 广州  
李灵辉 广东省疾病预防控制中心公共卫生应急部, 511430, 广州  
梁文佳 广东省疾病预防控制中心公共卫生应急部, 511430, 广州  
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中文摘要:
      目的 掌握1990--2012年广东省登革热和基孔肯稚热感染状况和流行态势。方法 采用回顾性调查及文献研究相结合的方法获取1990--2012年广东省登革热和基孔肯雅热疫情及病原学监测资料,采集健康人群血清进行登革病毒(DENv)和基孔肯雅病毒(CHIKV)-IgG特异性抗体检测。结果 1995、2002、2006年广东省出现3个登革热流行高峰,发病率分别为9.75/10万、1.76/10万、1.25/10万。1990~1994年优势毒株为DENV-2和DENV-4型;1995年开始DENV-1型主导的流行模式持续近13年;2009年开始多种血清型合并流行。2003--2012年从7 718份健康人血清中检出DENV-IgG特异性抗体阳性标本180份,阳性率2.33%;2012年对采集的2132份健康人血清进行CHIKV-IgG特异性抗体检测,结果均为阴性。结论 广东省登革热感染水平总体较低,近年来由DENV-1型主导的流行模式逐步向多型并存的局面过渡,部分地区开始呈现地方化迹象。人群对CHIKV缺乏基本的免疫屏障,应加强监测与防控。
英文摘要:
      Objective To understand the status of infection and epidemic trend of Dengue fever and Chikungunya in Guangdong. Methods Retrospective survey and literature review were used to obtain data on the incidence, etiology of Dengue and Chikungunya. Serological survey was conducted to detect the specific-antibodies in healthy individuals for both Dengue virus (DENY) and Chikungunya virus (CHIKV). Results Three epidemics of Dengue fever were observed during 1990-2012, with the annual incidence rates as 9.75/100 000 in 1995,1.76/100 000 in 2002 and 1.25/100 000 in 2006, respectively. The predominant epidemic strains appeared to be DENV-2 and DENY-4 during 1990-1994. Since 1995, DENV-1 had become the predominant transmission strain which lasted for almost 13 years. Co-existence of muitipie serotypes of DENY started in 2009. Of the 7 718 sera from healthy population during 2003-2012 , 180 specimens were detected positive for specific DENY IgG antibo, ended with a sero-prevalence rate of 2.33%.All 2 132 sera in 2012 were detected negative for CHIKV IgG antibody. Conclusion The overall exposure level to Dengue was considered to be low in Guangdong province. However, the predominant transmission mode caused by DENY-1 had been gradually changed into the co-existence of multiple serotypes with the endemic signs appeared in some part of the areas. Chikungunya was a newly emerging disease in Guangdong since local people were lack of basic immunity barrier. Surveillance and control programs thus seemed important.
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