文章摘要
王强,徐春雨,徐东群,刘传合,陈育智.中国城市儿童哮喘危险因素分析[J].中华流行病学杂志,2014,35(3):237-241
中国城市儿童哮喘危险因素分析
Risks on asthma among city chiidren in China:a nationwide case-control study
收稿日期:2013-10-30  出版日期:2014-09-18
DOI:
中文关键词: 儿童哮喘;危险因素;病例对照研究
英文关键词: Childhood asthma;Risk factor;Case-control study
基金项目:全国儿童哮喘协作组、中国疾病预防控制中心环境与健康相关产品安全所联合发起“第三次全国儿童哮喘流行病学调查”
作者单位E-mail
王强 中国疾病预防控制中心环境与健康相关产品安全所, 北京 100050 dongqunxu@126.con 
徐春雨 中国疾病预防控制中心环境与健康相关产品安全所, 北京 100050  
徐东群 中国疾病预防控制中心环境与健康相关产品安全所, 北京 100050  
刘传合 首都儿科研究所  
陈育智 首都儿科研究所  
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中文摘要:
      目的分析中国城市儿童哮喘特征及其危险因素。方法采用成组病例对照研究,以2010年全国43个城市0~14岁儿童哮喘调查中临床确诊的全部哮喘病例为病例组(12 450人),与病例年龄、性别匹配者为对照组(14 500人),采用全国统一设计、以ISAAC(TheInternational Study ofAsthma andAllergies in Childhood)环境因素问卷为基础的哮喘调查问卷,通过Z检验、广义线性混合效应模型(GLMM)分析阐述儿童哮喘的危险因素。结果纳入调查对象共计26 950人(男:女=1.55:1)。经GLMM分析,年龄、民族、性别、过敏史、家族史、母亲职业、抗生素用药史、早产、剖宫产、蛋白辅食添加时间、烹词燃料、使用空调、房屋装修、家人吸居室霉斑及家庭种植花草为中国城市儿童哮喘的主要影响因素(P<0.05);部分危险因素对新发病例和现患病例影响程度不同,室内种植花草对新发哮喘(OR=2.09,95%CI:1.30~3.36)和现患哮喘(OR=O.80,95%C1:O.74一O.86)影响的差异有统计学意义。哮喘危险因素冈年龄而异,<3岁组哮喘主要影响素为过敏、感染、气味刺激和早产(OR=1.72,95%CI:1.42。2.08),3。5岁组的危险因素增加了性别(OR=1.18,95%CI:1.03-1.35)、低出生体重(OR=1.69,95%CI:1.17~2.44)和剖宫产(OR=1.26,95%CI:1.10~2.45):_6~14岁组的危险因素增加了年龄(OR=O.97,95%CI:0.95~O.99)、民族(0冠=1.61,95%C7:1.26一,2.06)和迁居(O露=1.68,95%Chl.39-2.03)。结论中国儿童哮喘的危险因素包括遗传、过敏、感染和其他环境因素,其机制有待进一步专题研究。
英文摘要:
      Objective To understand the epidemiological characteristics of hepatitis C in Henan province.Methods Multistage sampling was used to investigate a group of 1-75 year-old general population,living in 30 districts of 18 cities,Henan province.Blood samples were collected and tested for anti-HCV and hepatitis C virus (HCV),from April to July 2012.Results 32 203 persons were investigated.Among the general population aged 1 to 75 years old,the overall prevalence rates of anti-HCV and HCV RNA were 0.64% and 0.35% respectively.The prevalence rates of anti-HCV among males and females were 0.60%,and 0.68% respectively,with the rates of HCV RNA as 0.37%,and 0.33% respectively.The prevalence rates of anti-HCV and HCV RNA were increasing with age.The prevalence rates of anti-HCV and HCV RNA in urban area were 0.58% and 0.32%,and in rural area as 0.41%,and 0.19% respectively.Conclusion After the implementation of comprehensive measures for HCV control and prevention,Henan province became low prevalent for HCV infection.Our data revealed that the overall prevalence remained low,but the epidemic was severe in some geographical regions in Henan province
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