| 李燕,施继红,林黎明,魏晓明,牛伯晖,孟令民,陈朔华,吴寿岭.血尿酸对男性人群全因死亡的影响[J].中华流行病学杂志,2014,35(6):650-654 |
| 血尿酸对男性人群全因死亡的影响 |
| Influence of blood uric acid on all-cause deaths |
| 收稿日期:2013-11-25 出版日期:2014-09-02 |
| DOI： |
| 中文关键词: 血尿酸 全因死亡 |
| 英文关键词: Serum uric acid All-cause mortality |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨血尿酸（SUA）水平对男性人群全因死亡的影响。方法 采取前瞻性队列研究方法，以2006－2007 年度参加开滦集团健康体检的81 110 名男性职工为研究对象，排除既往有心肌梗死、脑卒中、恶性肿瘤病史及肾小球滤过率（eGFR）＜30 ml/（min·1.73 m2）、服用对SUA有影响的药物者;进行统一问卷调查、血液生化检查，平均随访（47.5±4.3）个月，依据2006－2007 年度SUA值将研究对象五等分，采用Cox比例风险模型分析SUA对男性人群全因死亡的影响。结果 （1）至2010－2011 年度随访结束，不同SUA五分位组死亡例数分别为315、278、243、292、341，对应全因死亡率分别为2.43%、2.36%、1.96%、2.42%、2.92%。（2）单因素Cox比例风险回归模型分析显示，以SUA第三分位组为参照，第一、二、四、五分位组发生全因死亡的HR值（95%CI）分别为1.32（1.11～1.56）、1.19（1.00～1.41）、1.20（1.01～1.43）、1.41（1.19～1.66）。（3）多因素Cox比例风险回归模型分析显示，校正年龄、SBP、DBP、BMI、TG、TC、HDL-C、LDL-C、FPG、高敏C反应蛋白、吸烟史、饮酒史、文化程度、职业、经济收入后，以SUA第三分位组为参照，第一、二、四、五分位组发生全因死亡的HR 值（95%CI）分别为1.26（1.06～1.51）、1.20（1.01～1.44）、1.25（1.05～1.49）、1.42（1.19～1.68）。结论 SUA为全因死亡的独立危险因素，该值过高或过低都将增加全因死亡的发病风险，其五分位组全因死亡率呈“U”形曲线。 |
| 英文摘要: |
| Objective To explore the association between serum uric acid（SUA）and allcause mortality in men. Methods In this prospective cohort study，data being used was derived from the Kailuan study cohort. A total of 81 110 male workers who had taken part in the Kailuan physical examination were enrolled. Subjects with previous myocardial infarction，stroke，cancer， eGFR＜30 ml/（min·1.73 m2）accidental deaths and those ever used drugs that seemed to have showed an effect on blood uric acid，were excluded. All the information was gathered from a unified questionnaire，measured by blood biochemistry and with the mean period of follow up as（47.5±4.3） months. Based on the 2006-2007 SUA value，observed objects were divided into five groups，with multivariate Cox proportional hazard regression analysis used to estimate the relationship between SUA and all-cause mortality in men. Results 1）At the end of the follow-up period in 2010-2011， the number of deaths were 315，278，243，292 and 341 among the different SUA quinte，with incidence rates of all-cause mortality as 2.43%，2.36%，1.96%，2.42% and 2.92%，respectively. 2）Data from the Single factor Cox proportional hazard regression analysis showed that，when comparing with the third quinte，HR values of the all-cause mortality were 1.32（1.11-1.56），1.19（1.00-1.41），1.20（1.01- 1.43）and 1.41（1.19-1.66）in other four groups，respectively. 3）When factors were adjusted for age， systolic blood pressure，diastolic blood pressure，body mass index，triglyceride，total cholesterol， high-density lipoprotein cholesterol， low density lipoprotein cholesterol， fasting glucose， high-sensitivity C-reactive protein，smoking history and history of drinking，education，profession， economy，etc.，results from the Multiple Cox proportional hazard regression analysis showed the HR values of the all-cause mortality were 1.26（1.06-1.51），1.20（1.01-1.44），1.25（1.05-1.49），1.42 （1.19-1.68）in other four groups，respectively，comparing to the third quinte. Conclusion Using SUA as the independent risk factor of all-cause mortality，the exceptional levels of SUA were associated with an increasing risk for all-cause mortality while the association of SUA with all-cause mortality appeared an“U”shaped curve. |
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