| 王义,陶杰,董岩,陈朔华,高新颖,季春鹏,杨光,郑瑶,吴寿岭.不同收缩压水平对臂踝脉搏波传导速度影响的研究[J].中华流行病学杂志,2014,35(6):655-659 |
| 不同收缩压水平对臂踝脉搏波传导速度影响的研究 |
| Effect of different levels of systolic blood pressure on brachial-ankle pulse wave velocity |
| 收稿日期:2013-11-03 出版日期:2014-09-02 |
| DOI： |
| 中文关键词: 收缩压 臂踝脉搏波传导速度 危险因素 |
| 英文关键词: Systolic blood pressure Brachial-ankle pulse wave velocity Risk factor |
| 基金项目:国家科技重大专项（2008ZX09312-008-004） |
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| 中文摘要: |
| 目的 探讨不同收缩压（SBP）水平对臂踝脉搏波传导速度（baPWV）的影响。方法 在101 510 名参加2006－2007 年开滦集团职工健康体检者中随机分层抽取5 852 人作为研究对象进行横断面研究，采用统一问卷调查、血液生化及baPWV检查，其中符合入选标准（年龄≥40 岁、既往无缺血性脑卒中、短暂性脑缺血发作、心肌梗死者）5 440 人，将资料完整的5 222 人纳入统计分析。依据2010－2011 年度体检时SBP值将研究对象分为理想SBP组（SBP＜120 mmHg）、正常高值Ⅰ期组（120 mmHg≤SBP＜130 mmHg）、正常高值Ⅱ期组（130 mmHg≤SBP＜140 mmHg）、高血压组（SBP≥140 mmHg或＜140 mmHg但正在服用降压药物者）。利用多因素logistic 回归分析不同SBP水平对baPWV的影响。结果 （1）5 222（男性3 132，女性2 090）名研究对象平均年龄55.1 岁，平均baPWV（1 587.57±400.71）cm/s，baPWV≥1 400 cm/s 的检出率为62%;（2）4 组人群平均baPWV分别为1 322.19、1 456.27、1 544.78、1 827.77 cm/s，baPWV≥1 400 cm/s 的检出率分别为26.4%、49.3%、64.2%、88.3%;（3）多因素线性回归分析显示SBP的标准化β 值为0.40，仅次于年龄的0.48;（4）影响baPWV的多因素logistic 回归分析显示，校正年龄、性别等因素后，与理想SBP组比较，正常高值Ⅰ期、正常高值Ⅱ期和高血压组均为baPWV≥1 400 cm/s 的危险因素，OR值分别为2.70（95% CI：2.20～3.32）、4.56（95% CI：3.67～5.67）和13.51（95% CI：10.87～16.78）。结论 SBP升高是baPWV增加的独立危险因素。 |
| 英文摘要: |
| Objective To investigate the impact of different levels of systolic blood pressure on brachial-ankle pulse wave velocity（baPWV）. Methods A total of 5 852 participants was selected with stratified random sampling from the 101 510 workers of Tangshan Kaiuan Company who had undergone a physical check-up program. 5 222 of them with integral data were recruited into this survey. According to SBP collected during the 2010-2011 health examination program，the population under observation was divided into four groups：optimal SBP（SBP＜120 mmHg），high-normal blood pressure Ⅰ period（120 mmHg≤SBP＜130 mmHg），high-normal blood pressure Ⅱ period （130 mmHg≤SBP＜140 mmHg）and hypertension（SBP≥140 mmHg or SBP＜140 mmHg but antihypertensive drug user）. Multivariate logistic regression analysis was used to analyze the influence of different levels of systolic blood pressure on baPWV. Results 1）There were 3 132 males and 2 090 females in all the 5 222 participants with an average age of 55.1 years old. Their mean of baPWV was（1 587.57±400.71）cm/s，with the detection rates as 62%（baPWV≥1 400 cm/s）. 2）The means of baPWV for the above groups of SBP were 1 322.19，1 456.27，1 544.78 and 1 827.77 cm/s， respectively，with detection rates of baPWV≥1 400 cm/s as 26.4%,49.3%,64.2% and 88.3%, respectively. 3）Results from the Multiple linear regression analysis revealed that β of SBP was 0.40，only ranking second，on age（0.48）. 4）Data from the Multiple logistic regression analysis showed that after adjusting for age，gender and other risk factors，when compared to optimal SBP，factors as high-normal blood pressure Ⅰ period、high-normal blood pressure Ⅱ period and hypertension were risk factors for increasing baPWV，with OR values as 2.70（95% CI：2.20-3.32），4.56（95% CI： 3.67-5.67）and 13.51（95% CI：10.87-16.78），respectively. Conclusion Higher SBP seemed an independent risk factor for the increase of baPWV. |
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