文章摘要
邓永岳,张春阳,严延生,颜苹苹,吴守丽.福建省HIV-1 新近感染者流行毒株基因亚型及其流行特征分析[J].中华流行病学杂志,2014,35(6):714-719
福建省HIV-1 新近感染者流行毒株基因亚型及其流行特征分析
Genetic subtype and epidemiological feature of HIV-1 circulating strains among recently infected patients in Fujian province
收稿日期:2014-02-12  出版日期:2014-09-02
DOI:
中文关键词: 艾滋病病毒;新近感染者;亚型
英文关键词: HIV-1;New recent infections;Subtype
基金项目:福建省卫生厅青年科研基金(2012-1-12)
作者单位E-mail
邓永岳 361004 厦门大学附属中山医院
福建医科大学公共卫生学院 
 
张春阳 福建省疾病预防控制中心  
严延生 福建省疾病预防控制中心 yysh@fjcdc.com.cn 
颜苹苹 福建省疾病预防控制中心  
吴守丽 福建省疾病预防控制中心  
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中文摘要:
      目的 了解福建省HIV-1 新近感染者流行毒株的亚型分布和流行特征。方法 随机抽取福建省2011-2012 年使用BED捕获酶免疫试验检出的104 例新近感染者血样标本,采用反转录巢式PCR扩增,gagpolenv 基因片段,并测定和分析核酸序列。结果 目标人群中存在B亚型和01_AE、07_BC、08_BC、55_01B 四种流行重组型,其中以01_AE 和07_BC 流行重组型为主,分别占45.68%和35.80%。基因亚型的流行特征分析显示,亚型分布中01_AE 所占比例下降,07_BC 所占比例上升;性传播是主要感染途径,其中同性传播比例明显上升。结论 福建省HIV-1 流行毒株亚型分布众多,随着时间推移,亚型构成和传播途径已发生改变,应加强对HIV-1感染的分子流行病学趋势动态监测。
英文摘要:
      Objective In order to evaluate the distribution of genetic subtypes and epidemiological feature of HIV-1 circulating strains in Fujian province. Methods Blood samples and epidemiological data were collected from 104 newly infected patients who were distinguished by BED-CEIA methodology,during 2011-2012. Viral sequences(n=81)of HIV-1 gagenv,and pol segments were amplified by nested PCR. Results Subtypes B and four Circulating Recombinant Forms,(CRF01_AE,CRF07_BC,CRF08_BC and CRF55_01B) were found in the samples, CRF01_AE(45.68%)and CRF07_BC(35.80%)were the two main HIV-1 strains in Fujian province. Compared with previous data,the proportion of CRF07_BC rose significantly while it gradually decreased in CRF01_AE. Heterosexual contact was still the principal transmission route in Fujian province,but the number of infection among men-who-have-sex-with- men grew rapidly. Conclusion Results from this study suggested that different subtypes of HIV-1 strain existed in Fujian province. The distribution of subtypes and the mode of transmission were changing with the progress of epidemic. Dynamic monitoring of the molecular epidemiology trends of HIV-1 infection should be enhanced.
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