低出生体重儿对产妇分娩后高血压患病率的影响

王立姣; 田琪; 武爱萍; 阚淑婷; 陶杰; 董岩; 韩红锋; 高新颖; 郑瑶; 陈朔华; 吴寿岭

文章摘要

王立姣,田琪,武爱萍,阚淑婷,陶杰,董岩,韩红锋,高新颖,郑瑶,陈朔华,吴寿岭.低出生体重儿对产妇分娩后高血压患病率的影响[J].中华流行病学杂志,2014,35(7):779-783

低出生体重儿对产妇分娩后高血压患病率的影响

Influence of low birth weight on the increased risk of post-partum hypertension

收稿日期:2014-01-06 出版日期:2014-09-01

DOI：10.3760/cma.j.issn.0254-6450.2014.07.005

中文关键词: 高血压低出生体重儿危险因素

英文关键词: Hypertension Low birth weight infant Risk factor

基金项目:

作者	单位	E-mail
王立姣	河北联合大学研究生院, 唐山 063000
田琪	河北联合大学附属开滦总医院
武爱萍	河北联合大学附属开滦总医院
阚淑婷	河北联合大学附属开滦总医院
陶杰	河北联合大学研究生院, 唐山 063000
董岩	林西医院
韩红锋	河北联合大学研究生院, 唐山 063000
高新颖	河北联合大学研究生院, 唐山 063000
郑瑶	河北联合大学研究生院, 唐山 063000
陈朔华	开滦员工健康保障中心
吴寿岭	河北联合大学附属开滦总医院	drwusl@163.com

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中文摘要:

目的探讨低出生体重儿（LBWI）对产妇分娩后高血压患病率的影响。方法采用回顾性队列研究设计, 收集1976 年10 月至2008 年12 月间在开滦医疗集团住院分娩且参加2010－2011 年度健康体检的3 172 例女性资料, 根据是否有低体重出生儿史, 分为LBWI组与非LBWI 组。观察两组的高血压患病情况, 采用多因素logistic 回归方法分析患高血压的影响因素。结果 3 172 例女性的平均年龄为42.3 岁, 其中LBWI 组147 例, 非LBWI 组3 025 例, 所生婴儿平均体重分别为2.31 kg 和3.39 kg。LBWI组高血压患者为35 例, 患病率为23.8%, 非LBWI组高血压患者为511 例, 患病率为16.9%（P＜0.05）。多因素logistic 回归分析结果显示, 校正分娩年龄、产后血压及查体时BMI、FPG、HDL-C、LDL-C、TC、TG、高敏C 反应蛋白后, LBWI 组妇女远期发生高血压的风险是非LBWI 组的1.60（95%CI：1.02～2.53）倍。结论有LBWI 史的妇女分娩后高血压的患病率高于无LBWI 史的妇女, 即有LBWI 史的妇女分娩后患高血压的风险增加。

英文摘要:

Objective To compare the prevalence of hypertension between low birth weightinfant（LBWI）women and non-LBWI women. Methods A retrospective cohort study was applied and 3 172 pregnant women giving births during October 1976 to December 2008 in our hospital and underwent physical check-up between 2010 and 2011 at the Kailuan medical group were included and divided into LBWI group and non-LBWI group by the history of LBWI. Prevalence of hypertension was obtained during the follow-up program. Multiple logistic regression analysis was used to assess the relative risk of hypertension. Results A total number of 3 172 women, with an average age of 42.3 years old were divided into LBWI group（n＝147）and non-LBWI group（n＝3 025）, with the average birth weights of their infants were 2.31 kg and 3.39 kg, respectively. The prevalence of hypertension from the follow-up program was significantly higher in LBWI group than that in the non-LBWI group（23.8% vs. 16.9%, P＜0.05）. After adjustment for other traditional risk factors, the risk of hypertension in LBWI group was 1.60（95%CI：1.02-2.53）folds higher than that in the non-LBWI group. Conclusion Prevalence of hypertension in women with LBWI was higher than that in those women without LBWI． History of LBWI seemed to have had an increased risk to develop hypertension.

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