文章摘要
杨辉,毛广运,张海洋,张传武,邱文婷,郭小娟.慢性砷暴露人群DNA氧化损伤与血脂异常关联性的研究[J].中华流行病学杂志,2014,35(7):802-805
慢性砷暴露人群DNA氧化损伤与血脂异常关联性的研究
Association between dyslipidemia and 8-OHdG/Cr among a population exposed to chronic arsenic
收稿日期:2013-12-19  出版日期:2014-09-01
DOI:10.3760/cma.j.issn.0254-6450.2014.07.010
中文关键词: 砷暴露, 慢性  8-羟基脱氧鸟苷/肌酐  血脂异常  DNA氧化损伤
英文关键词: Chronic arsenic exposure  8-OHdG/Cr  Dyslipidemia  Oxidative DNA damage
基金项目:浙江省自然科学基金(Y2110454);浙江省科技厅项目(2013c33169);温州市科技局项目(H20100025)
作者单位E-mail
杨辉 温州医科大学环境与公共卫生学院, 325035  
毛广运 温州医科大学环境与公共卫生学院, 325035  
张海洋 温州医科大学环境与公共卫生学院, 325035  
张传武 温州医科大学环境与公共卫生学院, 325035  
邱文婷 温州医科大学环境与公共卫生学院, 325035  
郭小娟 温州医科大学环境与公共卫生学院, 325035 gxj@wzmc.edu.cn 
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中文摘要:
      目的 探讨慢性砷暴露人群DNA氧化损伤与血脂异常的关联性。方法 采用分层整群抽样方法, 随机抽取某饮水型高砷暴露地区407 名慢性砷暴露者作为调查对象, 检测其血脂水平, 并据此分为血脂正常组、HDL-C比值异常组、高TC血症组和HDL-C比值异常合并高TC血症组。采集调查对象晨尿, 并使用ELISA试剂盒测定其DNA氧化损伤的关键性标志物8-羟基脱氧鸟苷/肌酐(8-OHdG/Cr)水平。采用广义线性回归模型调整相关混杂因素后, 分析慢性砷暴露人群DNA氧化损伤与血脂异常的关联性。结果 4 组人群8-OHdG/Cr 水平M(Q1~Q3)分别为51.43(36.86~68.57)、55.73(39.90~79.94)、58.08(44.94~69.91)和65.28(49.29~92.95)ng/mg, 各组间差异有统计学意义(P=0.006)。广义线性回归模型进一步表明, 在校正血压、文化程度、暴露年限、BMI、FPG、性别、主动吸烟、被动吸烟、吸烟指数和饮酒等潜在的混杂因素后, HDL-C比值异常合并高TC血症组8-OHdG/Cr水平与血脂水平呈现出显著正相关(P=0.018), 且8-OHdG/Cr水平与其血脂异常程度间存在明显的线性趋势(P=0.016)。结论 慢性砷暴露人群8-OHdG/Cr水平与其血脂状态间存在显著的关联性, 血脂异常程度越严重, 其DNA氧化损伤越明显。
英文摘要:
      Objective To explore the association between dyslipidemia and the level of 8-OHdG/Cr in urine among a population exposed to chronic arsenic. Methods Four hundred and seven subjects were randomly selected in an arsenic-affected area in Inner Mongolia. After blood biochemical examination, all the subjects were divided into 4 groups based on the results of total cholesterol(TC), triglycerides(TG), high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C). The groups consisted of hypercholesterolemia, HDL-C ratio anomaly, combined hypercholesterolemia and HDL-C ratio anomaly, as well as a normal lipid group. Urine samples were collected and 8-OHdG/Cr was measured using the ELISA method. A generalized linear mixed model was used to analyze the association between dyslipidemia and 8-OHdG/Cr. Results The levels of 8-OHdG/Cr as 55.73(39.90-79.94)ng/mg, 58.08(44.94-69.91)ng/mg, 65.28 (49.29-92.95)ng/mg and 51.43(36.86-68.57)ng/mgin the HDL-C ratio anomaly, hypercholesterolemia, combined hypercholesterolemia and HDL-C ratio anomaly groups and the control group, respectively, which showed significant differences on the levels of 8-OHdG/Cr in the four groups(P=0.006). From the linear regression analysis results showed that the 8-OHdG/Cr level incombined hypercholesterolemia and HDL-C ratio anomaly group was higher(4.25 ± 0.55 ng/mg)than in the control group(3.96±0.55 ng/mg)(P=0.018). After adjusting for important covariates, there was a linear trend between the levels of 8-OHdG/Cr and dyslipidemia(P=0.016). Conclusion Data from our study showed a linear relation between hypercholesterolemia, HDL-C ratio anomaly and the 8-OHdG/Cr level, suggesting that dyslipidemia was associated with oxidative DNA damage among those arsenic-affected people.
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