| 杨辉,毛广运,张海洋,张传武,邱文婷,郭小娟.慢性砷暴露人群DNA氧化损伤与血脂异常关联性的研究[J].中华流行病学杂志,2014,35(7):802-805 |
| 慢性砷暴露人群DNA氧化损伤与血脂异常关联性的研究 |
| Association between dyslipidemia and 8-OHdG/Cr among a population exposed to chronic arsenic |
| 收稿日期:2013-12-19 出版日期:2014-09-01 |
| DOI：10.3760/cma.j.issn.0254-6450.2014.07.010 |
| 中文关键词: 砷暴露, 慢性 8-羟基脱氧鸟苷/肌酐 血脂异常 DNA氧化损伤 |
| 英文关键词: Chronic arsenic exposure 8-OHdG/Cr Dyslipidemia Oxidative DNA damage |
| 基金项目:浙江省自然科学基金（Y2110454）；浙江省科技厅项目（2013c33169）；温州市科技局项目（H20100025） |
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| 中文摘要: |
| 目的 探讨慢性砷暴露人群DNA氧化损伤与血脂异常的关联性。方法 采用分层整群抽样方法, 随机抽取某饮水型高砷暴露地区407 名慢性砷暴露者作为调查对象, 检测其血脂水平, 并据此分为血脂正常组、HDL-C比值异常组、高TC血症组和HDL-C比值异常合并高TC血症组。采集调查对象晨尿, 并使用ELISA试剂盒测定其DNA氧化损伤的关键性标志物8-羟基脱氧鸟苷/肌酐（8-OHdG/Cr）水平。采用广义线性回归模型调整相关混杂因素后, 分析慢性砷暴露人群DNA氧化损伤与血脂异常的关联性。结果 4 组人群8-OHdG/Cr 水平M（Q1～Q3）分别为51.43（36.86～68.57）、55.73（39.90～79.94）、58.08（44.94～69.91）和65.28（49.29～92.95）ng/mg, 各组间差异有统计学意义（P＝0.006）。广义线性回归模型进一步表明, 在校正血压、文化程度、暴露年限、BMI、FPG、性别、主动吸烟、被动吸烟、吸烟指数和饮酒等潜在的混杂因素后, HDL-C比值异常合并高TC血症组8-OHdG/Cr水平与血脂水平呈现出显著正相关（P＝0.018）, 且8-OHdG/Cr水平与其血脂异常程度间存在明显的线性趋势（P＝0.016）。结论 慢性砷暴露人群8-OHdG/Cr水平与其血脂状态间存在显著的关联性, 血脂异常程度越严重, 其DNA氧化损伤越明显。 |
| 英文摘要: |
| Objective To explore the association between dyslipidemia and the level of 8-OHdG/Cr in urine among a population exposed to chronic arsenic. Methods Four hundred and seven subjects were randomly selected in an arsenic-affected area in Inner Mongolia. After blood biochemical examination, all the subjects were divided into 4 groups based on the results of total cholesterol（TC）, triglycerides（TG）, high density lipoprotein cholesterol（HDL-C）and low density lipoprotein cholesterol（LDL-C）. The groups consisted of hypercholesterolemia, HDL-C ratio anomaly, combined hypercholesterolemia and HDL-C ratio anomaly, as well as a normal lipid group. Urine samples were collected and 8-OHdG/Cr was measured using the ELISA method. A generalized linear mixed model was used to analyze the association between dyslipidemia and 8-OHdG/Cr. Results The levels of 8-OHdG/Cr as 55.73（39.90-79.94）ng/mg, 58.08（44.94-69.91）ng/mg, 65.28 （49.29-92.95）ng/mg and 51.43（36.86-68.57）ng/mgin the HDL-C ratio anomaly, hypercholesterolemia, combined hypercholesterolemia and HDL-C ratio anomaly groups and the control group, respectively, which showed significant differences on the levels of 8-OHdG/Cr in the four groups（P＝0.006）. From the linear regression analysis results showed that the 8-OHdG/Cr level incombined hypercholesterolemia and HDL-C ratio anomaly group was higher（4.25 ± 0.55 ng/mg）than in the control group（3.96±0.55 ng/mg）（P＝0.018）. After adjusting for important covariates, there was a linear trend between the levels of 8-OHdG/Cr and dyslipidemia（P＝0.016）. Conclusion Data from our study showed a linear relation between hypercholesterolemia, HDL-C ratio anomaly and the 8-OHdG/Cr level, suggesting that dyslipidemia was associated with oxidative DNA damage among those arsenic-affected people. |
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