文章摘要
吴佳慧,张金涛,许锬,张欢,张永红,张绍艳.中性粒细胞比率、血糖水平与急性脑梗死患者短期预后的关系[J].中华流行病学杂志,2014,35(7):861-864
中性粒细胞比率、血糖水平与急性脑梗死患者短期预后的关系
Neutrophil ratio/blood glucose and poor short outcome among patients with acute ischemic stroke
收稿日期:2013-10-30  出版日期:2014-09-01
DOI:10.3760/cma.j.issn.0254-6450.2014.07.023
中文关键词: 急性脑梗死  中性粒细胞比率  血糖  短期预后
英文关键词: Acute ischemic stroke  Neutrophils ratio  Blood glucose  Short outcome
基金项目:国家自然科学基金青年基金(81102190)
作者单位E-mail
吴佳慧 苏州大学医学部公共卫生学院流行病学教研室, 215123  
张金涛 解放军济南军区第88医院神经内科  
许锬 苏州大学医学部公共卫生学院流行病学教研室, 215123  
张欢 苏州大学医学部公共卫生学院流行病学教研室, 215123  
张永红 苏州大学医学部公共卫生学院流行病学教研室, 215123  
张绍艳 苏州大学医学部公共卫生学院流行病学教研室, 215123 zhangsy@suda.edu.cn 
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中文摘要:
      目的 探讨急性脑梗死患者入院时中性粒细胞比率、血糖水平与其短期预后的关系。方法 以山东省4 家医院的2 265 例急性脑梗死住院患者为研究对象, 通过查阅病历档案, 收集患者入院时的人口统计学资料、生活方式、疾病史、家族史及实验室资料等。研究终点事件定义为患者出院评分NIHSS≥5 或住院期间死亡。将研究对象分为4 组:中性粒细胞比率、血糖均正常组(NN/NG);中性粒细胞比率正常、血糖高组(NN/IG);中性粒细胞比率高、血糖正常组(IN/NG);中性粒细胞比率、血糖均高组(IN/IG)。采用非条件logistic 回归分析中性粒细胞比率、血糖与急性脑梗死短期预后的关系。结果 急性脑梗死患者终点事件发生组的中性粒细胞比率和血糖高于未发生组, 差异有统计学意义(均P<0.05)。经多因素调整后, 与NN/NG相比, NN/IG、IN/NG 和IN/IG 组发生终点事件的OR 值(95%CI)分别为1.356(0.942~1.953)、1.879(1.113~3.171)和2.210(1.477~3.307)。结论 急性脑梗死患者入院时中性粒细胞比率是其短期预后不良的独立危险因素。IN/IG 发生短期预后不良的危险最大。中性粒细胞比率/血糖水平可作为急性脑梗死短期预后不良的预测指标。
英文摘要:
      Objective To investigate the relationship between neutrophil ratio/blood glucose and short outcome among patients with acute ischemic stroke admitted to hospitals. Methods A total of 2 265 acute ischemic stroke patients in four hospitals in Shandong province were included in this study. Through access to patients’files, data on demographic, lifestyle, medical history, family history and laboratory findings were collected from all participants at admission. Endpoint of the study was defined as poor short-term prognosis of acute cerebral infarction(NIHSS≥5)at discharge or death during hospitalization. Subjects of this study were divided into four groups:normal neutrophil ratio with normal blood glucose(NN/NG);normal neutrophil ratio with high blood glucose(NN/IG);high neutrophil ratio with normal blood glucose(IN/NG)and high neutrophil ratio with high blood glucose(IN/IG). Non-conditional logistic regression analysis was used to evaluate the association between blood glucose/neutrophil ratio and the short outcome of acute ischemic stroke.Results Neutrophil ratio and the level of blood glucose in patients with study endpoints were both higher than those without the study endpoints, and the difference was statistically significant(all P<0.05)。After multivariate adjustment, when compared to NN/NG group, the ORs(95% CI)of NN/IG, IN/NG and IN/IG group were 1.356(0.942-1.953), 1.879(1.113-3.171)and 2.210(1.477-3.307), respectively. Conclusion Neutrophil ratio at admission was an independent risk factor of poor short outcome in patients with acute ischemic stroke. IN/IG group was considered at a highest risk in general population. Neutrophil ratio/glucose was valuable in predicting the incidence of poor short outcome in acute ischemic stroke patients.
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