文章摘要
张盼,娄培安,常桂秋,张雷,陈培培,李婷,乔程,董宗美.睡眠质量及时间与2型糖尿病风险交互作用的研究[J].中华流行病学杂志,2014,35(9):990-993
睡眠质量及时间与2型糖尿病风险交互作用的研究
Interaction between quality and duration of sleep on the prevalence of type 2 diabetes
投稿时间:2014-03-31  
DOI:10.3760/cma.j.issn.0254-6450.2014.09.004
中文关键词: 2型糖尿病;睡眠质量;睡眠时间;交互作用
英文关键词: Type 2 diabetes;Sleep quality;Sleep duration;Interaction
基金项目:2012年度江苏省卫生厅预防医学科研课题(Y2012025); 2011年度徐州市科技计划项目(XF11C090); 2012年徐州市双百人才培养工程项目(BRA201224)
作者单位E-mail
张盼 221006 江苏省徐州市疾病预防控制中心
徐州医学院 
 
娄培安 221006 江苏省徐州市疾病预防控制中心
徐州医学院 
lpa82835415@126.com 
常桂秋 221006 江苏省徐州市疾病预防控制中心  
张雷 221006 江苏省徐州市疾病预防控制中心  
陈培培 221006 江苏省徐州市疾病预防控制中心  
李婷 221006 江苏省徐州市疾病预防控制中心  
乔程 221006 江苏省徐州市疾病预防控制中心  
董宗美 221006 江苏省徐州市疾病预防控制中心  
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中文摘要:
      目的 探讨睡眠质量和睡眠时间与2型糖尿病(T2DM)的关系,并分析两者间对T2DM交互作用的强度。方法 采用横断面研究方法于2013年3-5月调查9 622名徐州市社区常住居民,利 用非条件logistic回归模型分析睡眠时间和睡眠质量与T2DM的关系,通过Bootstrap法计算相对超额危险度比(RERI)、归因比(AP)和交互作用指数(S)以评价睡眠时间和睡眠质量之间的相加交互 作用。结果 T2DM患者和非T2DM患者的匹兹堡睡眠质量量表各组分及总分比较,除入睡时间和催眠药物外,其他差异均有统计学意义(P<0.01)。睡眠质量好者与睡眠质量差者相比、睡眠时间6~8 h与睡眠时间<6 h者相比,T2DM患病率差异均有统计学意义(P<0.01)。调整性别、年龄、文化程度、职业、糖尿病家族史、吸烟、饮酒、非职业性体育活动、BMI等混杂因素后,睡眠质量差且睡眠 时间<6 h者与睡眠质量好且睡眠时间在6~8 h者相比,罹患糖尿病的风险高 3.78倍(OR=4.78,95%CI:3.32~6.99);睡眠质量差且睡眠时间>8 h者,罹患T2DM的风险增加0.92倍(OR=1.92, 95%CI:1.18~3.31);睡眠质量差合并每天睡眠时间<6 h对发生T2DM的交互作用分别为RERI=2.33(95%CI:1.23~8.79),AP=0.67(95%CI:0.21~0.83),S=6.87(95%CI:2.33~10.75); 睡眠质量差合并每天睡眠时间>8 h对发生T2DM的交互作用分别为RERI=0.33(95%CI:-0.12~1.13),AP=0.17(95%CI:-0.03~0.51),S=1.56(95%CI:0.76~2.74)。结论 睡眠质量差和睡 眠时间短对罹患T2DM有正相加交互作用。
英文摘要:
      Objective To explore the effects related to quality and duration of sleep and their interactions on the prevalence of type-2 diabetes (T2DM). Methods 9 622 people aged 18 years and over were recruited for our cross-sectional study during March 2013 to May 2013. Unconditional logistic regression was used to analyze the relationship between quality and duration of sleep on T2DM. Bootstrap was used to calculate the relative excess risk of interaction (RERI),the attributable proportion (AP) of interaction and the synergy index (SI). 95% confidence intervals (CI) of RERI,AP and SI were estimated. Results Concerning the comparison between cases and controls on both individual and total scores,other scores were all significantly different (P<0.01),except for two items (time for falling asleep and drugs for hypnosis). The prevalence of T2DM in volunteers with poor sleeping quality was higher than that in volunteers with good sleeping quality (P<0.01). Individuals with sleep duration <6 hours had a higher prevalence of T2DM,when compared with individuals with sleep duration of 6-8 hours (P<0.01). After adjusting for age,gender,level of education, occupation,family history of diabetes,status on cigarette smoking,alcohol intake,physical activities and body mass index (BMI),the prevalence of T2DM appeared the highest in those with poor sleeping quality and short duration (OR=4.78,95%CI:3.32-6.99;P<0.01),when compared with those who had good sleep quality and 6-8 h sleep duration. The risk of T2DM still increased in people who had poor sleep or long duration (OR=1.92,95%CI:1.18-3.31;P<0.01). Values of RERI,AP and SI(with 95%CI) were 2.33(1.23-8.79), 0.67(0.21-0.83) and 6.87(2.33-10.75),respectively,for the interaction between poor sleep quality and short sleep duration,while 0.33(-0.12-1.13),0.17(-0.03-0.51),1.56(0.76-2.74) for the interaction between good sleep quality and long sleep duration. Conclusion Our results suggested that there were additive interactions between poor quality and shorter duration of sleep.
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