| 王林,帅平,刘玉萍,程幼夫,杨华,李婷欣,龚立荣,任姣姣,王洪佳.血脂水平对血压正常高值人群脉搏波传导速度的影响[J].中华流行病学杂志,2014,35(9):1058-1061 |
| 血脂水平对血压正常高值人群脉搏波传导速度的影响 |
| Effect of blood lipid on the change of brachial-ankle pulse wave velocity among prehypertensive population |
| 收稿日期:2014-07-15 出版日期:2014-09-11 |
| DOI：10.3760/cma.j.issn.0254-6450.2014.09.020 |
| 中文关键词: 血脂异常 脉搏波传导速度 脂蛋白比值 血压正常高值 动脉僵硬度 |
| 英文关键词: Abnormal blood lipid Pulse wave velocity Lipoprotein ration Prehypertension Arterial stiffness |
| 基金项目:四川省卫生厅科研项目（090438） |
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| 中文摘要: |
| 目的 探讨血脂和脂蛋白比值对血压正常高值人群脉搏波传导速度的影响。方法 选择11 611名血压正常的健康体检者，分为正常血压值组（血压<120/80 mmHg）和血压正常高值组（血压为120～139/80～89 mmHg）。应用全自动动脉硬化仪测定入选者肱踝脉搏波传导速度（baPWV），同时测量身高、体重、FPG、TC、TG、HDL-C、LDL-C等指标，并计算HDL-C和TC/HDL-C比值、LDL-C/HDL-C比值。分析血脂和脂蛋白比值异常情况对不同血压组脉搏波传导速度的影响。结果 血压正常高值组的baPWV异常率均高于血压正常组。血压正常组中除HDL-C外，TC、TG、LDL-C、TC/HDL-C、 LDL-C/HDL-C的升高均使baPWV的异常率显著增加（P<0.001）。血压正常高值组中，TC和LDL-C的升高使baPWV的异常率显著增加（P<0.001）。多元logistic回归分析显示，除年龄、BMI、FPG外， TC/HDL-C异常是血压正常组动脉僵硬度增高的独立危险因子（OR=1.732），TG异常是血压正常高值组的独立危险因素（OR=1.301）。结论 在正常血压不同水平下，血脂和脂蛋白比值的异常是动 脉僵硬度增高的独立危险因素。 |
| 英文摘要: |
| Objective To explore the effect of blood lipid and lipoprotein ratios on the change of brachial-ankle pulse wave velocity(baPWV) among prehypertensive subjects. Methods 11 611 subjects with normal blood pressure(BP) were divided into two groups,which was one with optimal blood pressure(BP<120/80 mmHg) and the other with prehypertension(BP:120-139/80-89 mmHg). Height,weight,baPWV,fasting blood-glucose,TC,TG,LDL-C and HDL-C were detected. Results The abnormal rate of baPWV in prehypertension group was obviously higher than that in the optimal blood pressure group. For optimal blood pressure group,the abnormality of TG,TC,LDL-C,TC/HDL-C as well as LDL-C/HDL-C,caused the increase of baPWV significantly (P<0.001). For prehypertensive group,the abnormality of TC and LDL-C caused the significant increase of baPWV(P<0.001). Results from logistic regression analysis showed that except for age,BMI and fasting blood-glucose,TC/HDL-C increasing was the independent risk factor in optimal blood pressure group,while TG increasing was for the prehypertension group. Conclusion With different normal BP level,both abnormality of blood lipid and lipoprotein ratio were the independent risk factors for baPWV increasing. |
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