| 陈铭灵,方红,张华,严玉洁,姚保栋,秦国友,徐望红.女性出生体重与2型糖尿病风险的跨代研究[J].中华流行病学杂志,2015,36(2):110-114 |
| 女性出生体重与2型糖尿病风险的跨代研究 |
| Birth weight and subsequent risk of type 2 diabetes across two generations in Chinese females |
| 收稿日期:2014-10-13 出版日期:2015-02-06 |
| DOI：10.3760/cma.j.issn.0254-6450.2015.02.002 |
| 中文关键词: 出生体重 糖尿病,2型 跨代效应 |
| 英文关键词: Birth weight Diabetes type 2 Cross-generation |
| 基金项目:上海市公共卫生学科带头人培养项目(GWDTR201204) |
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| 摘要点击次数: 3291 |
| 全文下载次数: 2013 |
| 中文摘要: |
| 目的 探索女性出生体重与T2DM的代际关联。方法 2012年11月至2013年1月对10 324名上海市有亲缘关系的2～4代女性开展横断面调查,通过问卷调查出生信息及T2DM史。将所有对象分成连续2代,共6 436对母女纳入分析。运用通径分析方法评估母代出生体重及T2DM患病状况对子代的影响;并采用中介效应分析方法分析子代出生体重是否为2代T2DM患病风险的中介因素。结果 2代人群的出生体重呈正相关,母代出生体重每增加1 kg,子代出生体重平均增加0.335 kg(95%CI:0.307～0.363).与无T2DM母亲的子代相比,患T2DM母亲的子代出生体重平均高0.066 kg(95%CI:0.025～0.107),患T2DM的风险增加3.173倍(95%CI:1.946～5.174).≥20岁研究对象中,调整年龄后,未见出生体重对成年期T2DM的影响。通径和中介分析显示,母代出生体重对子代出生体重的影响较大;子代出生体重高是母代患T2DM与子代患T2DM的中介因素,并减弱了二者关联的2.8%.结论 母代出生体重及T2DM状况对子代出生体重及成年后的T2DM风险有一定影响。 |
| 英文摘要: |
| Objective To evaluate the association between birth weight and subsequent risk of type 2 diabetes (T2DM) across two generations in Chinese females. Methods A cross-sectional survey was conducted among 10 324 blood-related females in Shanghai from November 2012 to January 2013. A structured questionnaire was used to collect data about demographic information,birth weight,lifestyle factors and diagnosis of T2DM. Path analysis was performed to estimate the maternal effect of birth weight and diabetes status on their offspring,and mediation analysis was conducted to test whether birth weight mediates the association between maternal and daughters' diabetes status. Results A positive association was observed between maternal and daughters' birth weight. One kg increase in maternal birth weight was associated with an average of 0.335(95%CI:0.307-0.363) kg elevated birth weight in female offspring. Maternal diabetes status was also related with an average of 0.066(95%CI:0.025-0.107) kg increase in birth weight and tripled risk of subsequent T2DM (OR=3.173,95%CI:1.946-5.174) in female offspring. In all subjects aged ≥20 years,no significant relationship was observed between birth weight and risk of T2DM subsequently after adjusting for age. Offspring's birth weight,as a mediator of maternal and daughters' diabetes status,explained 2.8% of their association. Conclusion Maternal birth weight and diabetes status may influence their female offspring's birth weight and subsequent risk of T2DM. |
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