| 余建兴,赖圣杰,王鑫,廖巧红,冯录召,冉陆,许文波,邱燕子,张子科,黎孟枫,吴建国,刘玮,袁正宏,陈瑜,赵世文,王新华,赵卓,余宏杰,景怀琦,李中杰,杨维中.中国27省(市、自治区)2009－2013年门诊腹泻病例诺如病毒流行特征分析[J].中华流行病学杂志,2015,36(3):199-204 |
| 中国27省(市、自治区)2009－2013年门诊腹泻病例诺如病毒流行特征分析 |
| Analysis of epidemiology characteristics of norovirus among diarrheal outpatients in 27 provinces in China, 2009-2013 |
| 收稿日期:2014-10-10 出版日期:2015-03-10 |
| DOI：10.3760/cma.j.issn.0254-6450.2015.03.003 |
| 中文关键词: 诺如病毒 腹泻病 哨点监测 基因分型 |
| 英文关键词: Norovirus Diarrhea disease Sentinel surveillance Genotyping |
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| 中文摘要: |
| 目的 了解我国门诊腹泻患者中诺如病毒的流行特征。方法 在国内27个省(市、自治区)173家医院的门/急诊中开展腹泻监测,收集腹泻病例临床和流行病学资料,同时采集病例粪便标本,送58家网络实验室采用RT-PCR检测诺如病毒,并分析2009－2013年不同地区、人群以及时间的诺如病毒检出率。结果 在34 031名腹泻监测病例中,有11.6%的病例检出诺如病毒。其中6～23月龄儿童和>45岁人群的检出率最高,分别为13.7%和12.4%。一年中以秋、冬季检出率较高;中温带和暖温带地区,诺如病毒在冬季检出率最高,分别为10.7%和11.6%;而亚热带地区,以秋季检出率最高(14.3%)。诺如病毒检出的主要型别为GⅡ组(89.9%)。结论 诺如病毒对我国各年龄组人群均有不同程度的影响,尤其在儿童和中老年门诊腹泻病例中较为常见,并呈现明显的季节性流行特征,且不同气候带地区的流行高峰存在差异。 |
| 英文摘要: |
| Objective To investigate the epidemiology characteristics of norovirus among diarrheal outpatients in China. Methods Diarrhea cases were monitored at emergency/outpatient departments at 173 hospitals in 27 provinces of China,with clinical and epidemiological data,and fecal specimens collected and sent to 58 network-laboratories to detect norovirus by RT-PCR method,and to analyze the positive rate of norovirus in various regions,population and time during 2009- 2013. Results 11.6% of the 34 031 diarrheal cases under surveillance were found with norovirus. Age group of 6-23 month-old children and that of people over 45 years old were found with the highest positive percentage,13.7% and 12.4% respectively. Positive percentage of norovirus peaks in autumn and winter in a year;it peaks in mid-temperate zones (10.7%) and warm-temperate zones (11.6%) in winter. It peaks in sub-tropical zones in autumn (14.3%). The most prevalent genogroups detected were norovirus GⅡ,accounting for 89.9% of identified strains. Conclusion Norovirus affects all ages and was most prevalent in children and the elderly among diarrhea outpatients. Norovirus' positive percentage showed strong seasonal pattern,and peaks at different times of a year in different climate zones of China. Since no effective preventive measures existed,further study on norovirus epidemiology and intervention strategies should be conducted in future. |
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