文章摘要
王娜,刘蒲,赵琦,赵燕萍,江峰,方红,付朝伟,许慧琳,王和兴,严玉洁,周颖,姜庆五.学龄儿童甲状腺容积相关因素分析及不同甲状腺容积指数比较[J].中华流行病学杂志,2015,36(3):237-240
学龄儿童甲状腺容积相关因素分析及不同甲状腺容积指数比较
An assessment of association of thyroid volume with growth indicators and comparison of different thyroid volume indexes in school-aged children
投稿时间:2014-10-27  
DOI:10.3760/cma.j.issn.0254-6450.2015.03.010
中文关键词: 甲状腺容积;甲状腺容积指数;学龄儿童
英文关键词: Thyroid volume;Thyroid volume index;School-age children
基金项目:卫生行业科研专项项目(201202012); 上海市公共卫生重点学科建设计划(12GWZX0101); 上海市卫生和计划生育委员会青年项目(20144Y0104); 复旦大学新进青年教师启动基金(20520131104)
作者单位E-mail
王娜 200021 上海, 复旦大学公共卫生学院流行病学教研室 教育部公共卫生安全重点实验室  
刘蒲 上海市闵行区疾病预防控制中心  
赵琦 200021 上海, 复旦大学公共卫生学院流行病学教研室 教育部公共卫生安全重点实验室 zhaoqi@shmu.edu.cn 
赵燕萍 上海市闵行区疾病预防控制中心  
江峰 200021 上海, 复旦大学公共卫生学院流行病学教研室 教育部公共卫生安全重点实验室  
方红 上海市闵行区疾病预防控制中心  
付朝伟 200021 上海, 复旦大学公共卫生学院流行病学教研室 教育部公共卫生安全重点实验室  
许慧琳 上海市闵行区疾病预防控制中心  
王和兴 200021 上海, 复旦大学公共卫生学院流行病学教研室 教育部公共卫生安全重点实验室  
严玉洁 上海市闵行区疾病预防控制中心  
周颖 200021 上海, 复旦大学公共卫生学院流行病学教研室 教育部公共卫生安全重点实验室  
姜庆五 200021 上海, 复旦大学公共卫生学院流行病学教研室 教育部公共卫生安全重点实验室  
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中文摘要:
      目的 分析学龄儿童甲状腺容积与体格发育的关系,比较不同甲状腺容积指数,为评价指标的选取提供参考。方法 采用分阶整群抽样方法,选定上海市闵行区某小学三至五年级共12个班级全体学生进行体格检查,测定身高、体重,计算BMI及体表面积(BSA),采用B超检查测定甲状腺容积,并分别计算不同甲状腺容积指数[身高容积指数(HVI)、体块容积指数(BMIV)、体重身高容积指数(WHVI)、体表面积容积指数(BSAV)]。采集尿样、盐样,测定尿碘及盐碘含量。分析不同测量指标与儿童生长发育指标的关联。结果 共获得485名学龄儿童甲状腺容积数据,其中男童258名(53.2%),女童227名(46.8%)。身高、体重、BMI及BSA均与年龄呈正相关(P<0.05)。相同年龄组内,甲状腺容积与体格发育指标均呈正相关。各甲状腺容积指数中,BSAV与体格发育因素之间的差异无统计学关联(与年龄、性别、身高、体重的偏相关系数分别为0.07、0.05、0.01和0.02,P>0.05),而甲状腺容积、HVI、BMIV及WHVI仍与年龄、身高、体重相关。结论 甲状腺容积受年龄、体重影响,单纯以年龄别甲状腺容积判断甲状腺肿有失偏颇;BSAV不受年龄、性别、体重、身高的影响,稳定性好,建议推荐使用。
英文摘要:
      Objective To analyze the association between thyroid volume and physical growth of school-age children,and to compare volume indexes of individual thyroids for reference of selection of assessment indicators. Methods All the students of the 12 classes of grades 3-5 at a primary school in Minhang district,Shanghai were rounded up with a multi- stage cluster sampling,for physical examinations to measure their height,weight,Body mass index(BMI) and body surface area (BSA),followed by B-ultrasonography to measure their thyroid volume. Data of the measurements were calculated to learn their height corrected volume index(HVI),weight and height corrected volume index(WHVI),BMI corrected volume(BMIV),and BSA corrected volume (BSAV) individually. Their urine and salt samples were collected to measure iodine concentration in urine and salt. Individual indexes were studied for their association with the growth and development indexes of children. Results Thyroid volume data were collected for 485 students,including 258 boys (53.2%) and 227 girls (46.8%). Their height,weight,BMI and BSA were found to be positively correlated with their age (P<0.05). For children of the same age group,their thyroid volume was also positively correlated with their physical development indexes. Of all the thyroid indexes,the difference between BSAV physical development factors had no statistical association (with partial-correlation coefficients for age,gender,height,and weight being 0.07,0.05,0.01 and 0.02 respectively),and their thyroid volume,HVI,BMI and weight were correlated to age,height and weight. Conclusion Thyroid volume was associated with age and weight. It was inappropriate to diagnose goiter with criteria of age,gender and thyroid volume. BSAV was recommended for its non-association with age,gender and weight and its stability.
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