文章摘要
王爱玲,王潇滟,窦丽霞,王芳,王前,乔亚萍,苏敏,金曦.中国HIV感染孕产妇早产及其影响因素分析[J].中华流行病学杂志,2015,36(4):349-353
中国HIV感染孕产妇早产及其影响因素分析
Incidence of and related risk factors on preterm delivery among HIV-infected pregnant women in China
收稿日期:2014-10-20  出版日期:2015-04-04
DOI:10.3760/cma.j.issn.0254-6450.2015.04.012
中文关键词: 人类免疫缺陷病毒;妊娠;早产
英文关键词: Human immunodeficiency virus;Pregnancy;Preterm delivery
基金项目:
作者单位E-mail
王爱玲 100101 北京, 中国疾病预防控制中心妇幼保健中心  
王潇滟 100101 北京, 中国疾病预防控制中心妇幼保健中心  
窦丽霞 100101 北京, 中国疾病预防控制中心妇幼保健中心  
王芳 100101 北京, 中国疾病预防控制中心妇幼保健中心  
王前 100101 北京, 中国疾病预防控制中心妇幼保健中心  
乔亚萍 100101 北京, 中国疾病预防控制中心妇幼保健中心  
苏敏 100101 北京, 中国疾病预防控制中心妇幼保健中心  
金曦 100101 北京, 中国疾病预防控制中心妇幼保健中心 jinxi@chinawch.org.cn 
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中文摘要:
      目的 了解目前我国HIV感染孕产妇早产的流行情况并探讨其相关影响因素。方法 数据来源于2013年我国预防艾滋病母婴传播管理信息系统。对HIV感染孕产妇的人口学特征、妊娠情况、HIV相关情况等变量进行分析, 计算早产发生率并探讨相关影响因素。结果 纳入分析的3 913例HIV感染孕产妇中有336例发生早产, 早产率为8.6%。分析发现我国HIV感染孕产妇早产与年龄、民族、文化程度、人口流动状态、有无妊娠高血压、是否为多胎妊娠、孕期随访次数等因素之间存在关联, 差异有统计学意义(P<0.05);与吸毒感染HIV者相比, 其他途径感染者早产率低(aOR=0.562, 95%CI:0.360~0.879)。在14~27孕周和在<14孕周就已开始使用抗反转录病毒药物(ARV)的孕产妇同妊娠期间从未使用过ARV药物的孕产妇相比早产发生危险性增加, aOR值分别为1.712(95%CI:1.196~2.451)和1.862(95%CI:1.261~2.749)。结论 早产是我国HIV感染孕产妇常见不良妊娠结局之一。HIV感染孕产妇早产不仅与传统危险因素相关, 还与HIV感染途径及孕期ARV药物服用情况相关。
英文摘要:
      Objective To measure the incidence rates of preterm delivery in HIV-infected pregnant women and to explore related potential risk factors. Methods Data from ‘Information System of Prevention of Mother-to-child Transmission of HIV Management in China, 2013’ was used in the study. Information regarding demographic characteristics, pregnancy, HIV relevant situations and pregnancy outcomes related to these HIV-infected pregnant women, were extracted and analyzed. Incidence of preterm delivery was calculated with related potential risk factors explored. Methods 3 913 HIV-infected pregnant women were involved in this study, including 336 of them having undergone preterm deliveries (8.6%). Results from univariate and multivariate analyses showed that preterm delivery was associated with factors as:maternal age, ethnicity, education, being migrant, pregnancy hypertension, multiple pregnancy and times of antenatal care visits (P<0.05) of the pregnant women. Compared with those who contracted the HIV infection through drug injection, the ones who were infected through other routes suffered fewer preterm deliveries (adjusted OR=0.562, 95%CI:0.360-0.879). Pregnant women who received antiretroviral therapy either between 14 to 27 gestational weeks or during the period of less than 14, were more likely to experience preterm delivery, comparison to those who did not receive the therapy during pregnancy. The adjusted ORs were 1.712(95%CI:1.196-2.451) and 1.862(95%CI:1.261-2.749), respectively. Conclusion Preterm delivery was a common adverse outcome during pregnancy among HIV-infected women in China. Other than traditionally known risk factors, routes of transmission and the use of antiretroviral therapy might also be associated with the increased risks for preterm delivery.
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