| 刘淼,何耀,吴蕾,王建华,杨姗姗,王义艳,张迪,曾静.北京社区老年人群代谢综合征与慢性肾脏病的关系及性别差异研究[J].中华流行病学杂志,2015,36(5):411-415 |
| 北京社区老年人群代谢综合征与慢性肾脏病的关系及性别差异研究 |
| Association between metabolic syndrome and chronic kidney disease and sex specific difference among community elder population in Beijing |
| 收稿日期:2014-10-22 出版日期:2015-05-12 |
| DOI：10.3760/cma.j.issn.0254-6450.2015.05.001 |
| 中文关键词: 代谢综合征 慢性肾脏病 横断面调查 性别差异 |
| 英文关键词: Metabolic syndrome Chronic kidney disease Cross-sectional study Sex specific difference |
| 基金项目:北京市科委重大科技课题(D121100004912003); 军事医学创新专项(13CXZ029); 解放军总医院苗圃基金(13KMM26) |
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| 中文摘要: |
| 目的 探讨社区老年人群MS与慢性肾脏病(CKD)的关系及其性别差异。方法 2009年9月至2010年6月采用两阶段整群随机抽样, 对北京市万寿路地区≥60岁老年人群进行横断面调查。MS诊断采用2009年国际统一标准定义;CKD诊断采用2012年国际肾脏病组织的标准定义。结果 共纳入2 102名(其中男性848名, 女性1 254名)社区老年人, 年龄60～95(67.9±5.8)岁。MS患病率为59.1%, CKD患病率为12.6%。随着MS组分数目的增加, CKD的患病率从2.9%增加至18.3%(趋势χ2检验P<0.001)。肾功能下降(2.0%增至8.6%)和白蛋白尿(1.9%增至12.1%)同样呈现增加的趋势(趋势χ2检验P<0.001)。多因素分析结果显示, 社区老年人群MS患者患肾功能下降、白蛋白尿、CKD风险是非MS患者的2.13(95%CI:1.39～2.26)倍、1.99(95%CI:1.41～2.82)倍和2.03(95%CI:1.52～2.71)倍。且随着MS组分数目的增加, 患病风险逐渐增加。不同性别比较, 女性人群中MS对肾功能下降(OR:3.30 vs. 1.27)、CKD(OR:2.19 vs. 1.89)患病的影响高于男性, 而对白蛋白尿的影响低于男性(OR:1.22 vs. 2.13)。结论 北京城区的社区老年人群MS与CKD患病风险相关, 且性别对于老年人群MS与CKD的关系有差异。 |
| 英文摘要: |
| Objective To evaluate the association between metabolic syndrome (MS) and chronic kidney disease (CKD) and its sex specific difference among community elder population in China. Methods A population-based cross-sectional study was conducted among the old people aged ≥60 years and selected through a two stage cluster random sampling in a community in Beijing from September 2009 to Jun 2010. The standard international case definitions of MS (2009) and CKD (2012) were used. Results A total of 2 102 old people aged 60-95 years, including 848 males and 1 254 females, were surveyed. The prevalence of MS and CKD were 59.1% and 12.6% respectively. The prevalence of CKD increased from 2.9% to 18.3% with the increase of the forms of MS. Multivariate logistic regression analysis showed the ORs of MS for decreased renal function, albuminuria and CKD were 2.13 (95%CI:1.39-2.26), 1.99 (95%CI:1.41-2.82) and 2.03 (95%CI:1.52-2.71) respectively, and the risk of CKD increased with the forms of MS. The impact of MS on decreased renal function was stronger in females (OR:2.19 vs. 1.89), but the impact of MS on albuminuria was stronger in males (OR:1.22 vs. 2.13). Conclusion There was a strong and sex specific association between MS and CKD among the community elder population in Beijing. |
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