文章摘要
李海,林玫,唐振柱,林新勤,谭毅,陈敏玫,钟豪杰,刘海燕,闭福银,林健燕,周树武,黄卓信.广西南宁市一起家庭聚集性人感染H7N9禽流感疫情的调查[J].中华流行病学杂志,2015,36(5):481-483
广西南宁市一起家庭聚集性人感染H7N9禽流感疫情的调查
Investigation of a family clustering of human infection with avian influenza A (H7N9) virus in Nanning, Guangxi
投稿时间:2014-12-01  
DOI:10.3760/cma.j.issn.0254-6450.2015.05.015
中文关键词: H7N9禽流感;聚集性;流行病学
英文关键词: Avian influenza A (H7N9);Cluster;Epidemiology
基金项目:
作者单位E-mail
李海 530028 南宁, 广西壮族自治区疾病预防控制中心  
林玫 530028 南宁, 广西壮族自治区疾病预防控制中心 gxlinmei@126.com 
唐振柱 530028 南宁, 广西壮族自治区疾病预防控制中心  
林新勤 南宁市疾病预防控制中心  
谭毅 530028 南宁, 广西壮族自治区疾病预防控制中心  
陈敏玫 530028 南宁, 广西壮族自治区疾病预防控制中心  
钟豪杰 广东省疾病预防控制中心  
刘海燕 南宁市疾病预防控制中心  
闭福银 530028 南宁, 广西壮族自治区疾病预防控制中心  
林健燕 南宁市疾病预防控制中心  
周树武 530028 南宁, 广西壮族自治区疾病预防控制中心  
黄卓信 南宁市横县疾病预防控制中心  
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中文摘要:
      目的 探讨南宁市一起人感染H7N9禽流感的传播模式。方法 应用现场流行病学方法调查2例病例及其82名密切接触者, 对采集的相关标本进行H7N9禽流感病毒核酸检测和病毒分离, 并分析基因序列和进化树同源性。结果 病例A在最后一次暴露于广东中山市活禽市场后4 d于当地发病, 并在发病后第2天返回广西南宁市横县家中。病例B(病例A之子, 5岁)无明确禽类接触史, 但与病例A同居一室密切接触, 4 d后发病。从2例中均分离出H7N9禽流感病毒, 2株病毒基因序列和系统进化树分析具有高度同源性, 且关系最近。指示病例(病例A)的其他81名密切接触者未出现人感染H7N9禽流感病毒症状。结论 二代病例(病例B)可能在无防护情况下密切接触指示病例而感染, 提示H7N9禽流感病毒可通过人-人传播, 但其传染力有限且非持续性。
英文摘要:
      Objective To understand the transmission mode of human infection with avian influenza A (H7N9) virus. Methods Field epidemiological investigation was conducted for a family clustering of human infection with H7N9 virus in Hengxian county, Guangxi Zhuang Autonomous Region in February 2014. Two patients and their 82 close contacts were surveyed. The samples collected from the patients, environments and poultry were tested by using real time reverse transcriptase-polymerase chain reaction (rRT-PCR), and the samples from patients were used for virus isolation. The samples from 5 close contacts were tested with RT-PCR. The clinical data, exposure histories of the patients and the detection results of the isolates and their homology were analyzed. Results Patient A became ill 4 days after her last exposure to poultry in Zhongshan, Guangdong province, and returned to her hometown in Hengxian 2 days after onset. Patient B was patient A's 5 years old son, who had no known exposure to poultry but slept with patient A for 4 days. He developed symptoms 4 days after last contact with his mother. Two strains of H7N9 virus were isolated from the two patients. The 2 isolates were highly homogenous(almost 100%) indicated by gene sequencing and phylogenetic tree. None of the other 81 close contacts developed symptoms of H7N9 virus infection. Conclusion Patients B was infected through close contact with patient A, indicating that avian H7N9 virus can spread from person to person, but the transmissibility is limited and non-sustainable.
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