文章摘要
苏通,李春霞,王君,陈卿,冯永亮,石璟,王素萍,梁晓峰.血液透析患者HBV感染影响因素的多水平模型分析[J].中华流行病学杂志,2015,36(5):510-514
血液透析患者HBV感染影响因素的多水平模型分析
Study on risk factors of hepatitis B virus infection among patients receiving hemodialysis by multi-level statistical model analysis
投稿时间:2014-11-15  
DOI:10.3760/cma.j.issn.0254-6450.2015.05.021
中文关键词: 血液透析;乙型肝炎病毒感染;多水平模型
英文关键词: Hemodialysis;Hepatitis B virus infection;Multi-level analysis model
基金项目:国家科技重大专项(2012ZX10002001-003-004); 山西医科大学博士启动基金(03201109); 山西省回国留学人员科研资助(2013-056)
作者单位E-mail
苏通 030001 太原, 山西医科大学公共卫生学院流行病学教研室  
李春霞 030001 太原, 山西医科大学公共卫生学院流行病学教研室  
王君 030001 太原, 山西医科大学公共卫生学院流行病学教研室  
陈卿 030001 太原, 山西医科大学公共卫生学院流行病学教研室  
冯永亮 030001 太原, 山西医科大学公共卫生学院流行病学教研室  
石璟 030001 太原, 山西医科大学公共卫生学院流行病学教研室  
王素萍 030001 太原, 山西医科大学公共卫生学院流行病学教研室 spwang88@163.com 
梁晓峰 中国疾病预防控制中心  
摘要点击次数: 1089
全文下载次数: 1145
中文摘要:
      目的 了解维持性血液透析(MHD)患者HBV感染现状, 并探讨相关影响因素。方法 2012年11月至2014年12月对山西省范围内16所医院血液透析中心1 524名MHD患者进行问卷调查, 收集研究对象一般人口学特征及可能的HBV感染危险因素等, 检测乙型肝炎(乙肝)血清学标志物5项。用SAS 9.3软件拟合两水平logistic回归模型分析HBV感染影响因素。结果1 524名MHD患者的HBsAg阳性率为5.25%, HBV感染率为38.85%, 不同医院之间感染率不同(t=2.33, P=0.034)。拟合两水平logistic回归零模型分析得到组内相关系数(ICC)=0.106 4, 约10.64%的总变异是由医院不同引起。引入解释变量后的结果显示, MHD患者50~65岁组的HBV感染率高于0~35岁组(OR=1.560, 95%CI:1.061~2.293);有拔牙史(OR=1.267, 95%CI:1.009~1.591)和乙肝家族史(OR=2.052, 95%CI:1.176~3.582)是HBV感染的危险因素;乙肝疫苗接种是HBV感染的保护因素(OR=0.734, 95%CI:0.541~0.996)。结论 不同医院间MHD患者HBV感染存在差异, 年龄组(50~65岁)、乙肝家族史及拔牙史为MHD患者HBV感染危险因素, 接种乙肝疫苗为保护因素。
英文摘要:
      Objective To understand the current status of HBV infection among patients receiving maintenance hemodialysis (MHD) and related influencing factors. Methods A questionnaire survey was conducted among 1 524 MHD patients selected from hemodialysis units in 16 hospitals in Shanxi province from 1 November 2012 to 30 December 2014 to collect their demographic information and learn about their risk behaviors. Serological detection was conducted for them. Statistical software package SAS 9.3 was used for fitting a two level logistic regression model to identify the independent risk factors for HBV infection. Results Among the 1 524 MHD patients, the positive rate of HBsAg was 5.25% and the HBV infection rate was 38.85%. The HBV infection rate varied with hospital (t=2.33, P=0.034). The two-level logistic regression empty model showed that intra-class correlation coefficient was 0.106 4, indicating that about 10.64% of the total variation was caused by the differences in hospitals. After introducing explaining variables, the results showed that the HBV infection rate in age group 50-65 years group was higher than that in age group 0-35 years (OR=1.560, 95%CI:1.061-2.293). Family history of HBV infection and dental surgery were the risk factors for HBV infection (OR=2.052 and 1.267, 95%CI:1.176-3.582 and 1.009-1.591). Receiving HepB vaccination was a protective factor for HBV infection (OR=0.734, 95%CI:0.541-0.996).Conclusion The HBV infection rates were different among MHD patients in different hospitals. Old age(50-65 years), family history of HBV infection and dental surgery were the risk factors and receiving HepB vaccination was a protective factor for HBV infection among MHD patients.
查看全文   Html全文     查看/发表评论  下载PDF阅读器
关闭